Small Cell Carcinoma of Uterine Cervix: A Case Report

Overview

Journal Caspian J Intern Med

Specialty General Medicine

Date 2024 Jul 16

PMID 39011443

Authors

Danial Fazilat-Panah

Mohammad Hassan Emranpour

Babak PeyroShabany

Sara Rasta

Maedeh Alsadat Fatemi

Zeinab Nazari

Yavar Rajabzadeh

Affiliations

Soon will be listed here.

Abstract

Background: Small cell carcinoma of cervix (SCCC) is a rare disease. SCCC is highly invasive and prone to distant metastatic spread and lymph node involvement. Here we aim to present a patient and her treatment.

Case Presentation: We report 47-year-old patient with history of breast cancer manifesting with abnormal vaginal bleeding diagnosed with SCCC. Patient underwent radical hysterectomy and bilateral salpingo-oophorectomy. Then, she received adjuvant chemoradiation postoperatively.

Conclusion: Small cell carcinoma of cervix is an aggressive form of cervical cancer with poor prognosis. Optimal treatment remains unsettled.

References

Hoskins P, Swenerton K, Pike J, Lim P, Aquino-Parsons C, Wong F . Small-cell carcinoma of the cervix: fourteen years of experience at a single institution using a combined-modality regimen of involved-field irradiation and platinum-based combination chemotherapy. J Clin Oncol. 2003; 21(18):3495-501. DOI: 10.1200/JCO.2003.01.501. View

Galanis E, Frytak S, Lloyd R . Extrapulmonary small cell carcinoma. Cancer. 1997; 79(9):1729-36. DOI: 10.1002/(sici)1097-0142(19970501)79:9<1729::aid-cncr14>3.0.co;2-#. View

Brennan S, Gregory D, Stillie A, Herschtal A, Manus M, Ball D . Should extrapulmonary small cell cancer be managed like small cell lung cancer?. Cancer. 2010; 116(4):888-95. DOI: 10.1002/cncr.24858. View

Tempfer C, Tischoff I, Dogan A, Hilal Z, Schultheis B, Kern P . Neuroendocrine carcinoma of the cervix: a systematic review of the literature. BMC Cancer. 2018; 18(1):530. PMC: 5935948. DOI: 10.1186/s12885-018-4447-x. View

Wong Y, Jack R, Mak V, Henrik M, Davies E . The epidemiology and survival of extrapulmonary small cell carcinoma in South East England, 1970-2004. BMC Cancer. 2009; 9:209. PMC: 2709640. DOI: 10.1186/1471-2407-9-209. View

Li X, Yang R, Jia Y, Zhou J, Ma D, Li S . Prognostic risk factors for small cell carcinoma of the cervix and impact of platinum-based neoadjuvant chemotherapy. Int J Gynaecol Obstet. 2015; 130(1):31-5. DOI: 10.1016/j.ijgo.2015.02.022. View

Chan J, Loizzi V, Burger R, Rutgers J, Monk B . Prognostic factors in neuroendocrine small cell cervical carcinoma: a multivariate analysis. Cancer. 2003; 97(3):568-74. DOI: 10.1002/cncr.11086. View

Viswanathan A, Deavers M, Jhingran A, Ramirez P, Levenback C, Eifel P . Small cell neuroendocrine carcinoma of the cervix: outcome and patterns of recurrence. Gynecol Oncol. 2004; 93(1):27-33. DOI: 10.1016/j.ygyno.2003.12.027. View

Roy S, Ko J, Bahl G . Small cell carcinoma of cervix: A population-based study evaluating standardized provincial treatment protocols. Gynecol Oncol Rep. 2019; 27:54-59. PMC: 6348692. DOI: 10.1016/j.gore.2019.01.003. View

10.

Kim J, Lee S, Park J, Kim H, Lee S, Nam E . Extrapulmonary small-cell carcinoma: a single-institution experience. Jpn J Clin Oncol. 2004; 34(5):250-4. DOI: 10.1093/jjco/hyh052. View

11.

Gardner G, Reidy-Lagunes D, Gehrig P . Neuroendocrine tumors of the gynecologic tract: A Society of Gynecologic Oncology (SGO) clinical document. Gynecol Oncol. 2011; 122(1):190-8. DOI: 10.1016/j.ygyno.2011.04.011. View

12.

Cohen J, Kapp D, Shin J, Urban R, Sherman A, Chen L . Small cell carcinoma of the cervix: treatment and survival outcomes of 188 patients. Am J Obstet Gynecol. 2010; 203(4):347.e1-6. DOI: 10.1016/j.ajog.2010.04.019. View

13.

Zhang Q, Xiong Y, Ye J, Zhang L, Li L . Influence of clinicopathological characteristics and comprehensive treatment models on the prognosis of small cell carcinoma of the cervix: A systematic review and meta-analysis. PLoS One. 2018; 13(4):e0192784. PMC: 5894955. DOI: 10.1371/journal.pone.0192784. View

14.

Castle P, Pierz A, Stoler M . A systematic review and meta-analysis on the attribution of human papillomavirus (HPV) in neuroendocrine cancers of the cervix. Gynecol Oncol. 2017; 148(2):422-429. DOI: 10.1016/j.ygyno.2017.12.001. View

15.

Albores-Saavedra J, Gersell D, Gilks C, Henson D, Lindberg G, Santiago H . Terminology of endocrine tumors of the uterine cervix: results of a workshop sponsored by the College of American Pathologists and the National Cancer Institute. Arch Pathol Lab Med. 1997; 121(1):34-9. View

16.

Chen J, Macdonald O, Gaffney D . Incidence, mortality, and prognostic factors of small cell carcinoma of the cervix. Obstet Gynecol. 2008; 111(6):1394-402. DOI: 10.1097/AOG.0b013e318173570b. View

17.

Lo Re G, Canzonieri V, Veronesi A, Dal Bo V, Barzan L, Zancanaro C . Extrapulmonary small cell carcinoma: a single-institution experience and review of the literature. Ann Oncol. 1994; 5(10):909-13. DOI: 10.1093/oxfordjournals.annonc.a058729. View

18.

Bhatla N, Aoki D, Sharma D, Sankaranarayanan R . Cancer of the cervix uteri. Int J Gynaecol Obstet. 2018; 143 Suppl 2:22-36. DOI: 10.1002/ijgo.12611. View

19.

Satoh T, Takei Y, Treilleux I, Devouassoux-Shisheboran M, Ledermann J, Viswanathan A . Gynecologic Cancer InterGroup (GCIG) consensus review for small cell carcinoma of the cervix. Int J Gynecol Cancer. 2014; 24(9 Suppl 3):S102-8. DOI: 10.1097/IGC.0000000000000262. View

20.

Sheets E, Berman M, Hrountas C, Liao S, Disaia P . Surgically treated, early-stage neuroendocrine small-cell cervical carcinoma. Obstet Gynecol. 1988; 71(1):10-4. View