Effects of Polyphenol-Rich Foods on Lipids and Oxidative Stress Status in Patients with Hyperlipidemia: A Systematic Review of Randomized Controlled Trials

Overview

Journal J Multidiscip Healthc

Publisher Dove Medical Press

Specialty Health Services

Date 2024 Jul 15

PMID 39006877

Authors

Yatian Jia

Qian Zhang

Yihua Zhang

Hui Wang

Qingmei Niu

Ruifang Zhu

Jia Li

Wen Fan

Yuexing Zhang

Affiliations

Soon will be listed here.

Abstract

Background: Hyperlipidemia has been demonstrated to be an autonomous predictor of numerous cardiovascular and cerebrovascular ailments, and research indicates that polyphenols have preventive and therapeutic effects on hyperlipidemia. Nevertheless, the impact of polyphenol-rich foods on blood lipids and oxidative stress status in patients with hyperlipidemia remains inconclusive.

Objective: To examine the impact of polyphenol-rich foods on lipid levels and oxidative stress in individuals with hyperlipidemia.

Methods: To retrieve papers published from the establishment of the database through October 9, 2023, eight databases were searched: the Chinese National Knowledge Infrastructure, the China Biomedical Literature Database, the Wanfang Database, the China Science and Technology Journal Database, PubMed, the Cochrane Library, Embase, and the Web of Science. The quality of include studies was assessed using the Cochrane Risk of Bias in Randomized Trials tool, v2.

Results: The study involved 13 surveys encompassing 640 patients diagnosed with hyperlipidemia. The scope of the food surveys included 12 commonly consumed food groups and medicinal and food homologous substances. All 13 studies reported the effects of polyphenol-rich foods on blood lipids, with significant improvements observed in blood lipid levels for 9 types of foods. Eight studies examined the impact on oxidative stress, and six foods demonstrated a significant reduction in oxidative stress levels. The observed effects were found to be influenced by factors such as dosage, duration of intervention, and gender.

Conclusion: Foods abundant in polyphenols play a crucial role in the prevention and treatment of hyperlipidemia by counteracting oxidative stress and regulating metabolic disorders. The confirmation of certain positive effects by several studies notwithstanding, discrepancies in results arise from various factors, necessitating further large-scale, prospective, well-designed randomized controlled studies to address this issue.

References

Napolitano A, Cascone A, Graziani G, Ferracane R, Scalfi L, Di Vaio C . Influence of variety and storage on the polyphenol composition of apple flesh. J Agric Food Chem. 2004; 52(21):6526-31. DOI: 10.1021/jf049822w. View

Alipoor B, Khadem Haghighian M, Sadat B, Asghari M . Effect of sesame seed on lipid profile and redox status in hyperlipidemic patients. Int J Food Sci Nutr. 2012; 63(6):674-8. DOI: 10.3109/09637486.2011.652077. View

Musolino V, Gliozzi M, Nucera S, Carresi C, Maiuolo J, Mollace R . The effect of bergamot polyphenolic fraction on lipid transfer protein system and vascular oxidative stress in a rat model of hyperlipemia. Lipids Health Dis. 2019; 18(1):115. PMC: 6525455. DOI: 10.1186/s12944-019-1061-0. View

Zhu Y, Ling W, Guo H, Song F, Ye Q, Zou T . Anti-inflammatory effect of purified dietary anthocyanin in adults with hypercholesterolemia: a randomized controlled trial. Nutr Metab Cardiovasc Dis. 2012; 23(9):843-9. DOI: 10.1016/j.numecd.2012.06.005. View

Troup R, Hayes J, Raatz S, Thyagarajan B, Khaliq W, Jacobs Jr D . Effect of black tea intake on blood cholesterol concentrations in individuals with mild hypercholesterolemia: a diet-controlled randomized trial. J Acad Nutr Diet. 2014; 115(2):264-271.e2. PMC: 4312726. DOI: 10.1016/j.jand.2014.07.021. View

Shidfar F, Ehramphosh E, Heydari I, Haghighi L, Hosseini S, Shidfar S . Effects of soy bean on serum paraoxonase 1 activity and lipoproteins in hyperlipidemic postmenopausal women. Int J Food Sci Nutr. 2008; 60(3):195-205. DOI: 10.1080/09637480701669463. View

Bloedon L, Balikai S, Chittams J, Cunnane S, Berlin J, Rader D . Flaxseed and cardiovascular risk factors: results from a double blind, randomized, controlled clinical trial. J Am Coll Nutr. 2008; 27(1):65-74. DOI: 10.1080/07315724.2008.10719676. View

Karr S . Epidemiology and management of hyperlipidemia. Am J Manag Care. 2017; 23(9 Suppl):S139-S148. View

Khongrum J, Yingthongchai P, Boonyapranai K, Wongtanasarasin W, Donrung N, Sukketsiri W . Antidyslipidemic, Antioxidant, and Anti-inflammatory Effects of Jelly Drink Containing Polyphenol-Rich Roselle Calyces Extract and Passion Fruit Juice with Pulp in Adults with Dyslipidemia: A Randomized, Double-Blind, Placebo-Controlled Trial. Oxid Med Cell Longev. 2022; 2022:4631983. PMC: 9519340. DOI: 10.1155/2022/4631983. View

10.

Xiao G, Zeng Z, Jiang J, Xu A, Li S, Li Y . Network pharmacology analysis and experimental validation to explore the mechanism of Bushao Tiaozhi capsule (BSTZC) on hyperlipidemia. Sci Rep. 2022; 12(1):6992. PMC: 9051129. DOI: 10.1038/s41598-022-11139-2. View

11.

Huang L, Xiao D, Zhang X, Sandhu A, Chandra P, Kay C . Strawberry Consumption, Cardiometabolic Risk Factors, and Vascular Function: A Randomized Controlled Trial in Adults with Moderate Hypercholesterolemia. J Nutr. 2021; 151(6):1517-1526. DOI: 10.1093/jn/nxab034. View

12.

Grosso G, Stepaniak U, Micek A, Stefler D, Bobak M, Pajak A . Dietary polyphenols are inversely associated with metabolic syndrome in Polish adults of the HAPIEE study. Eur J Nutr. 2016; 56(4):1409-1420. PMC: 5486632. DOI: 10.1007/s00394-016-1187-z. View

13.

Moosavian S, Maharat M, Chambari M, Moradi F, Rahimlou M . Effects of tart cherry juice consumption on cardio-metabolic risk factors: A systematic review and meta-analysis of randomized-controlled trials. Complement Ther Med. 2022; 71:102883. DOI: 10.1016/j.ctim.2022.102883. View

14.

Zhang Q, Jia Y, Zhang Y, Wang Y, Li X, Tian X . The effects of medicinal and food homologous substances on blood lipid and blood glucose levels and liver function in patients with nonalcoholic fatty liver disease: a systematic review of randomized controlled trials. Lipids Health Dis. 2023; 22(1):137. PMC: 10464055. DOI: 10.1186/s12944-023-01900-5. View

15.

Koutsos A, Riccadonna S, Ulaszewska M, Franceschi P, Trost K, Galvin A . Two apples a day lower serum cholesterol and improve cardiometabolic biomarkers in mildly hypercholesterolemic adults: a randomized, controlled, crossover trial. Am J Clin Nutr. 2019; 111(2):307-318. PMC: 6997084. DOI: 10.1093/ajcn/nqz282. View

16.

Burton-Freeman B, Linares A, Hyson D, Kappagoda T . Strawberry modulates LDL oxidation and postprandial lipemia in response to high-fat meal in overweight hyperlipidemic men and women. J Am Coll Nutr. 2010; 29(1):46-54. DOI: 10.1080/07315724.2010.10719816. View

17.

Rothwell J, Perez-Jimenez J, Neveu V, Medina-Remon A, Mhiri N, Garcia-Lobato P . Phenol-Explorer 3.0: a major update of the Phenol-Explorer database to incorporate data on the effects of food processing on polyphenol content. Database (Oxford). 2013; 2013:bat070. PMC: 3792339. DOI: 10.1093/database/bat070. View

18.

Tenore G, DAvino M, Caruso D, Buonomo G, Acampora C, Caruso G . Effect of Annurca Apple Polyphenols on Intermittent Claudication in Patients With Peripheral Artery Disease. Am J Cardiol. 2018; 123(5):847-853. DOI: 10.1016/j.amjcard.2018.11.034. View

19.

Cumpston M, Li T, Page M, Chandler J, Welch V, Higgins J . Updated guidance for trusted systematic reviews: a new edition of the Cochrane Handbook for Systematic Reviews of Interventions. Cochrane Database Syst Rev. 2019; 10:ED000142. PMC: 10284251. DOI: 10.1002/14651858.ED000142. View

20.

Heshmati J, Morvaridzadeh M, Sepidarkish M, Fazelian S, Rahimlou M, Omidi A . Effects of Melissa officinalis (Lemon Balm) on cardio-metabolic outcomes: A systematic review and meta-analysis. Phytother Res. 2020; 34(12):3113-3123. DOI: 10.1002/ptr.6744. View