Interrelationship Between Thyroid Hormones and Reduced Renal Function, a Review Article

Overview

Journal Thyroid Res

Specialty Endocrinology

Date 2024 Jul 14

PMID 39004740

Authors

Sadaf Agahi

Atieh Amouzegar

Mohammadjavad Honarvar

Fereidoun Azizi

Ladan Mehran

Affiliations

Soon will be listed here.

Abstract

Background: Understanding the relationship of thyroid hormones with the development of chronic kidney disease (CKD) has important clinical implications for managing patients with both thyroid and kidney dysfunction. In this review, our purpose was to provide a thorough comprehension of the interplay between thyroid hormones, thyroid dysfunctions, and CKD. While there is evidence linking thyroid hormone levels to renal diseases, the association between thyroid hormones, specifically within the normal range, and the risk of CKD incidence is still a subject of debate. The Google Scholar, PubMed, Scopus, and Web of Science, were searched using the medical subject heading (MeSH) terms for the relevant keywords up to December 2023.

Conclusion: Based on the review, the development of CKD is more consistently associated with higher serum TSH and thereafter lower serum free T3 levels; however, its association with free T4 is more controversial. Furthermore, subclinical and overt hypothyroidisms were considerably associated with incident CKD. Hyperthyroidism and Hashimoto thyroiditis might increase the risk of CKD.

References

Schultheiss U, Daya N, Grams M, Seufert J, Steffes M, Coresh J . Thyroid function, reduced kidney function and incident chronic kidney disease in a community-based population: the Atherosclerosis Risk in Communities study. Nephrol Dial Transplant. 2016; 32(11):1874-1881. PMC: 5837276. DOI: 10.1093/ndt/gfw301. View

Kovesdy C . Epidemiology of chronic kidney disease: an update 2022. Kidney Int Suppl (2011). 2022; 12(1):7-11. PMC: 9073222. DOI: 10.1016/j.kisu.2021.11.003. View

Dousdampanis P, Trigka K, Vagenakis G, Fourtounas C . The thyroid and the kidney: a complex interplay in health and disease. Int J Artif Organs. 2014; 37(1):1-12. DOI: 10.5301/ijao.5000300. View

Zhou J, Li H, Zhu X, Song H, Zhao Y, Yang J . Subclinical hypothyroidism and the risk of chronic kidney disease in T2D subjects: A case-control and dose-response analysis. Medicine (Baltimore). 2017; 96(15):e6519. PMC: 5403080. DOI: 10.1097/MD.0000000000006519. View

Kim H, Park S, Park H, Byun D, Suh K, Yoo M . Subclinical thyroid dysfunction and chronic kidney disease: a nationwide population-based study. BMC Nephrol. 2023; 24(1):64. PMC: 10031940. DOI: 10.1186/s12882-023-03111-7. View

Pappa T, Heydarpour M, Williams J, Hopkins P, Adler G, Alexander E . The Role of Thyroid in Renovascular Function: Independent Association of Serum TSH With Renal Plasma Flow. J Clin Endocrinol Metab. 2021; 106(9):e3327-e3334. PMC: 8372660. DOI: 10.1210/clinem/dgab390. View

Kazempour-Ardebili S, Amouzegar A, Tohidi M, Amouzegar A, Azizi F . Prevalence of Subclinical Hypothyroidism in Chronic Kidney Disease in a Population-based Study: Tehran Thyroid Study. Int J Endocrinol Metab. 2021; 19(2):e103750. PMC: 8198616. DOI: 10.5812/ijem.103750. View

Iglesias P, Bajo M, Selgas R, Diez J . Thyroid dysfunction and kidney disease: An update. Rev Endocr Metab Disord. 2016; 18(1):131-144. DOI: 10.1007/s11154-016-9395-7. View

Huang C, Li B, Reynolds K, Jacobsen S, Rhee C, Sim J . Association between hypothyroidism and chronic kidney disease observed among an adult population 55 years and older. Medicine (Baltimore). 2020; 99(17):e19569. PMC: 7220776. DOI: 10.1097/MD.0000000000019569. View

10.

Li J, Wu X, Luo M, Yan M, Wang Q, Li P . Association of Serum Thyroid Hormones with the Risk and Severity of Chronic Kidney Disease Among 3563 Chinese Adults. Med Sci Monit. 2020; 26:e922910. PMC: 7331475. DOI: 10.12659/MSM.922910. View

11.

Camara de Souza A, Arantes M, Zatz R, Elias R, Lopes R, Macedo E . Influence of low free thyroxine on progression of chronic kidney disease. BMC Nephrol. 2020; 21(1):36. PMC: 6993384. DOI: 10.1186/s12882-019-1677-3. View

12.

Peters J, Roumeliotis S, Mertens P, Liakopoulos V . Thyroid hormone status in patients with impaired kidney function. Int Urol Nephrol. 2021; 53(11):2349-2358. DOI: 10.1007/s11255-021-02800-2. View

13.

Schultheiss U, Steinbrenner I, Nauck M, Schneider M, Kotsis F, Baid-Agrawal S . Thyroid function, renal events and mortality in chronic kidney disease patients: the German Chronic Kidney Disease study. Clin Kidney J. 2021; 14(3):959-968. PMC: 8328092. DOI: 10.1093/ckj/sfaa052. View

14.

Zhang Y, Chang Y, Ryu S, Cho J, Lee W, Rhee E . Thyroid hormone levels and incident chronic kidney disease in euthyroid individuals: the Kangbuk Samsung Health Study. Int J Epidemiol. 2014; 43(5):1624-32. DOI: 10.1093/ije/dyu126. View

15.

Toda A, Hara S, Kato M, Tsuji H, Arase Y . Association of Thyrotropin Concentration with Chronic Kidney Disease in a Japanese General Population Cohort. Nephron. 2019; 142(2):91-97. DOI: 10.1159/000497326. View

16.

Basu G, Mohapatra A . Interactions between thyroid disorders and kidney disease. Indian J Endocrinol Metab. 2012; 16(2):204-13. PMC: 3313737. DOI: 10.4103/2230-8210.93737. View

17.

Endo K, Tanaka M, Sato T, Mori K, Hosaka I, Mikami T . A high level of thyroid-stimulating hormone is a risk factor for the development of chronic kidney disease in men: a 10-year cohort study. Hypertens Res. 2023; 47(3):663-671. DOI: 10.1038/s41440-023-01453-1. View

18.

Chaker L, Sedaghat S, Hoorn E, den Elzen W, Gussekloo J, Hofman A . The association of thyroid function and the risk of kidney function decline: a population-based cohort study. Eur J Endocrinol. 2016; 175(6):653-660. DOI: 10.1530/EJE-16-0537. View

19.

Ke C, Liang J, Liu M, Liu S, Wang C . Burden of chronic kidney disease and its risk-attributable burden in 137 low-and middle-income countries, 1990-2019: results from the global burden of disease study 2019. BMC Nephrol. 2022; 23(1):17. PMC: 8727977. DOI: 10.1186/s12882-021-02597-3. View

20.

Yang S, Lai S, Wang Z, Liu A, Wang W, Guan H . Thyroid Feedback Quantile-based Index correlates strongly to renal function in euthyroid individuals. Ann Med. 2021; 53(1):1945-1955. PMC: 8567884. DOI: 10.1080/07853890.2021.1993324. View