Does Serum Uric Acid Mediate Relation Between Healthy Lifestyle and Components of Metabolic Syndrome?

Overview

Journal Nutrients

Date 2024 Jul 13

PMID 38999885

Authors

Yan Huang

Hui Jing

Ziping Wang

Zongkai Li

Samuel Chacha

Yuxin Teng

Baibing Mi

Binyan Zhang

Yezhou Liu

Qiang Li

Yuan Shen

Jiaomei Yang

Yang Qu

Duolao Wang

Hong Yan

Shaonong Dang

Affiliations

Soon will be listed here.

Abstract

A healthy lifestyle is related to metabolic syndrome (MetS), but the mechanism is not fully understood. This study aimed to examine the association of components of MetS with lifestyle in a Chinese population and potential mediation role of serum uric acid (SUA) in the association between lifestyle behaviors and risk of components of MetS. Data were derived from a baseline survey of the Shaanxi urban cohort in the Regional Ethnic Cohort Study in northwest China. The relationship between components of MetS, healthy lifestyle score (HLS), and SUA was investigated by logistic or linear regression. A counterfactual-based mediation analysis was performed to ascertain whether and to what extent SUA mediated the total effect of HLS on components of MetS. Compared to those with 1 or less low-risk lifestyle factors, participants with 4-5 factors had 43.6% lower risk of impaired glucose tolerance (OR = 0.564; 95%CI: 0.408~0.778), 60.8% reduction in risk of high blood pressure (OR = 0.392; 95%CI: 0.321~0.478), 69.4% reduction in risk of hypertriglyceridemia (OR = 0.306; 95%CI: 0.252~0.372), and 47.3% lower risk of low levels of HDL cholesterol (OR = 0.527; 95%CI: 0.434~0.641). SUA mediated 2.95% (95%CI: 1.81~6.16%) of the total effect of HLS on impaired glucose tolerance, 14.68% (95%CI: 12.04~18.85%) on high blood pressure, 17.29% (95%CI: 15.01~20.5%) on hypertriglyceridemia, and 12.83% (95%CI: 10.22~17.48%) on low levels of HDL cholesterol. Increased HLS tends to reduce risk of components of MetS partly by decreasing the SUA level, which could be an important mechanism by which lifestyle influences MetS.

References

Raya-Cano E, Vaquero-Abellan M, Molina-Luque R, de Pedro-Jimenez D, Molina-Recio G, Romero-Saldana M . Association between metabolic syndrome and uric acid: a systematic review and meta-analysis. Sci Rep. 2022; 12(1):18412. PMC: 9626571. DOI: 10.1038/s41598-022-22025-2. View

Shahin L, Patel K, Heydari M, Kesselman M . Hyperuricemia and Cardiovascular Risk. Cureus. 2021; 13(5):e14855. PMC: 8174391. DOI: 10.7759/cureus.14855. View

Yan D, Tu Y, Jiang F, Wang J, Zhang R, Sun X . Uric Acid is independently associated with diabetic kidney disease: a cross-sectional study in a Chinese population. PLoS One. 2015; 10(6):e0129797. PMC: 4451151. DOI: 10.1371/journal.pone.0129797. View

Ford E, Giles W, Dietz W . Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA. 2002; 287(3):356-9. DOI: 10.1001/jama.287.3.356. View

Galassi A, Reynolds K, He J . Metabolic syndrome and risk of cardiovascular disease: a meta-analysis. Am J Med. 2006; 119(10):812-9. DOI: 10.1016/j.amjmed.2006.02.031. View

Yang H, Cui Z, Quan Z . Effects of Metabolic Syndrome and Its Components on Chronic Kidney Disease and Renal Function: A Two-Sample Mendelian Randomization Study. Metab Syndr Relat Disord. 2023; 22(2):114-122. DOI: 10.1089/met.2023.0161. View

Copur S, Demiray A, Kanbay M . Uric acid in metabolic syndrome: Does uric acid have a definitive role?. Eur J Intern Med. 2022; 103:4-12. DOI: 10.1016/j.ejim.2022.04.022. View

Niu M, Chen J, Hou R, Sun Y, Xiao Q, Pan X . Emerging healthy lifestyle factors and all-cause mortality among people with metabolic syndrome and metabolic syndrome-like characteristics in NHANES. J Transl Med. 2023; 21(1):239. PMC: 10068159. DOI: 10.1186/s12967-023-04062-1. View

Wakabayashi I . Inverse associations between serum urate and glycemic status in a general population and in persons with diabetes mellitus. Diabetol Metab Syndr. 2020; 12:21. PMC: 7063759. DOI: 10.1186/s13098-020-00528-0. View

10.

Viazzi F, Piscitelli P, Giorda C, Ceriello A, Genovese S, Russo G . Metabolic syndrome, serum uric acid and renal risk in patients with T2D. PLoS One. 2017; 12(4):e0176058. PMC: 5396926. DOI: 10.1371/journal.pone.0176058. View

11.

Li Q, Lu J, Cao X, Shi T, Feng J, Yang J . An Increase in Normal SUA Level Within the Normal Range Predicts Risk of Metabolic Syndrome, Especially in Women: A Cross-Sectional Study. Horm Metab Res. 2017; 49(5):338-342. DOI: 10.1055/s-0042-117010. View

12.

Wang J, Wang Y, Chen F, Ma G, Wang D . Measurement of the Combined Levels of Serum Uric Acid and Alanine Aminotransferase and the Risk of Metabolic Syndrome in a Population Aged 60 Years or More in Northeastern China. Med Sci Monit. 2020; 26:e916459. PMC: 6990664. DOI: 10.12659/MSM.916459. View

13.

Fan M, Sun D, Zhou T, Heianza Y, Lv J, Li L . Sleep patterns, genetic susceptibility, and incident cardiovascular disease: a prospective study of 385 292 UK biobank participants. Eur Heart J. 2019; 41(11):1182-1189. PMC: 7071844. DOI: 10.1093/eurheartj/ehz849. View

14.

He X, Shao W, Yu S, Yu J, Huang C, Ren H . Healthy lifestyle scores associate with incidence of type 2 diabetes mediated by uric acid. Nutr Metab (Lond). 2023; 20(1):47. PMC: 10619235. DOI: 10.1186/s12986-023-00763-y. View

15.

Bandaru P, Shankar A . Association between Serum Uric Acid Levels and Diabetes Mellitus. Int J Endocrinol. 2011; 2011:604715. PMC: 3216382. DOI: 10.1155/2011/604715. View

16.

Kanbay M, Jensen T, Solak Y, Le M, Roncal-Jimenez C, Rivard C . Uric acid in metabolic syndrome: From an innocent bystander to a central player. Eur J Intern Med. 2015; 29:3-8. PMC: 4826346. DOI: 10.1016/j.ejim.2015.11.026. View

17.

Chu Y, Sun S, Huang Y, Gao Q, Xie X, Wang P . Metagenomic analysis revealed the potential role of gut microbiome in gout. NPJ Biofilms Microbiomes. 2021; 7(1):66. PMC: 8352958. DOI: 10.1038/s41522-021-00235-2. View

18.

Maiuolo J, Oppedisano F, Gratteri S, Muscoli C, Mollace V . Regulation of uric acid metabolism and excretion. Int J Cardiol. 2015; 213:8-14. DOI: 10.1016/j.ijcard.2015.08.109. View

19.

Sotos-Prieto M, Bhupathiraju S, Falcon L, Gao X, Tucker K, Mattei J . Association between a Healthy Lifestyle Score and inflammatory markers among Puerto Rican adults. Nutr Metab Cardiovasc Dis. 2016; 26(3):178-84. PMC: 4788524. DOI: 10.1016/j.numecd.2015.12.004. View

20.

Zhang H, Li Y, Mao Z, Liu X, Zhang X, Yang K . Sex-specific associations of serum uric acid with metabolic syndrome in Chinese rural population: The RuralDiab study. Clin Chim Acta. 2018; 480:119-125. DOI: 10.1016/j.cca.2018.02.003. View