Synthesis, Characterization, X-ray Molecular Structure, Antioxidant, Antifungal, and Allelopathic Activity of a New Isonicotinate-Derived -Tetraarylporphyrin

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2024 Jul 13

PMID 38999116

Authors

Nour Elhouda Dardouri

Soukaina Hrichi

Pol Torres

Raja Chaabane-Banaoues

Alessandro Sorrenti

Thierry Roisnel

Ilona Turowska-Tyrk

Hamouda Babba

Joaquim Crusats

Albert Moyano

Habib Nasri

Affiliations

Soon will be listed here.

Abstract

The present article describes the synthesis of an isonicotinate-derived -arylporphyrin, that has been fully characterized by spectroscopic methods (including fluorescence spectroscopy), as well as elemental analysis and HR-MS. The structure of an -hexane monosolvate has been determined by single-crystal X-ray diffraction analysis. The radical scavenging activity of this new porphyrin against the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical has been measured. Its antifungal activity against three yeast strains ( ATCC 90028, ATCC 64677, and ATCC 64677) has been tested using the disk diffusion and microdilution methods. Whereas the measured antioxidant activity was low, the porphyrin showed moderate but encouraging antifungal activity. Finally, a study of its effect on the germination of lentil seeds revealed interesting allelopathic properties.

Citing Articles

Crystal structure, Hirshfeld surface analysis, DFT and mol-ecular docking studies of ethyl 5-amino-2-bromo-isonicotinate.

Mahadevaiah H, Shivanna H, Hanumaiah A, Hirehalli Chikkegowda D, Bandrehalli Siddagangaiah P Acta Crystallogr E Crystallogr Commun. 2025; 80(Pt 12):1274-1279.

PMID: 39906785 PMC: 11789189. DOI: 10.1107/S2056989024010594.

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