Recent Progress on Multi-Component Reactions Involving Nucleophile, Arynes and CO

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2024 Jul 13

PMID 38999103

Authors

Shaoxuan Gong

Xiumei Xie

Hongxia Sun

Yuting Liu

Junjie Li

Zhen Zhang

Affiliations

Soon will be listed here.

Abstract

Carbon dioxide (CO) is a non-toxic, abundant and recoverable source of carbon monoxide. Despite its thermodynamically stable and kinetically inert nature, research on CO utilisation is ongoing. CO-based aryne reactions, crucial for synthesising -substituted benzoic acids and their cyclisation products, have garnered significant attention, and multi-component reactions (MCRs) involving CO, aryne and nucleophilic reagents have been extensively studied. This review highlights recent advancements in CO capture reactions utilising phenylalkyne reactive intermediates. Mechanistic insights into these reactions are provided together with prospects for further development in this field.

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