Heteronuclear Complexes of Hg(II) and Zn(II) with Sodium Monensinate As a Ligand

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2024 Jul 13

PMID 38999058

Authors

Ivayla Pantcheva

Nikolay Petkov

Elzhana Encheva

Stiliyan Kolev

Svetlana Simova

Aleksandar Tsanev

Petar Dorkov

Angel Ugrinov

Affiliations

Soon will be listed here.

Abstract

The commercial veterinary antibiotic sodium monensinate (MonNa) binds mercury(II) or zinc(II) cations as thiocyanate [Hg(MonNa)(SCN)] () or isothiocyanate [Zn(MonNa)(NCS)] () neutral coordination compounds. The structure and physicochemical properties of and were evaluated by the methods of single crystal and/or powder X-ray diffraction, infrared, nuclear magnetic resonance, X-ray photoelectron spectroscopies, and electrospray-mass spectrometry. The primary cores of the two complexes comprise HgSO () and ZnNO () coordination motifs, respectively, due to the ambidentate binding modes of the SCN-ligands. The directly bound oxygen atoms originate from the carboxylate function of the parent antibiotic. Sodium cations remain in the hydrophilic cavity of monensin and cannot be replaced by the competing divalent metal ions. Zinc(II) binding does not influence the monensin efficacy in the case of and whereas the antimicrobial assay reveals the potential of complex as a therapeutic candidate for the treatment of infections caused by , , and .

Citing Articles

Cobalt(II) and Manganese(II) Complexes of Sodium Monensinate A Bearing Nitrate Co-Ligands.

Petkov N, Boyadzhiev M, Bozhilova N, Dorkov P, Encheva E, Ugrinov A Int J Mol Sci. 2024; 25(22).

PMID: 39596195 PMC: 11593825. DOI: 10.3390/ijms252212129.

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