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Early Management for Fracture-Related Infection: A Literature Review

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Specialty Health Services
Date 2024 Jul 13
PMID 38998841
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Abstract

Fracture-related infections (FRIs), as shown in the literature, represent one of the main complications of trauma surgery. They are a consequence of an implant-related "biofilm" formation and are a challenge for surgeons, microbiologists, and infectious disease specialists. For a correct diagnosis, careful clinical evaluation, to look for signs/symptoms attributable to an infectious condition, and instrumental examinations, to highlight the site of infection, its extent, and its severity, are both essential. Unfortunately, due to the lack of data in the literature, there is no consensus about guidelines on the diagnosis and treatment of FRIs. The purpose of this study is to present an up-to-date concept evaluation of the diagnostic procedures and treatment options available in the management of fracture-related infections.

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References
1.
Metsemakers W, Morgenstern M, Senneville E, Borens O, Govaert G, Onsea J . General treatment principles for fracture-related infection: recommendations from an international expert group. Arch Orthop Trauma Surg. 2019; 140(8):1013-1027. PMC: 7351827. DOI: 10.1007/s00402-019-03287-4. View

2.
Govaert G, Kuehl R, Atkins B, Trampuz A, Morgenstern M, Obremskey W . Diagnosing Fracture-Related Infection: Current Concepts and Recommendations. J Orthop Trauma. 2019; 34(1):8-17. PMC: 6903359. DOI: 10.1097/BOT.0000000000001614. View

3.
Vicenti G, Bizzoca D, Nappi V, Pesce V, Solarino G, Carrozzo M . Serum biomarkers in the diagnosis of periprosthetic joint infection: consolidated evidence and recent developments. Eur Rev Med Pharmacol Sci. 2019; 23(2 Suppl):43-50. DOI: 10.26355/eurrev_201904_17473. View

4.
Marais L, Hungerer S, Eckardt H, Zalavras C, Obremskey W, Ramsden A . Key aspects of soft tissue management in fracture-related infection: recommendations from an international expert group. Arch Orthop Trauma Surg. 2023; 144(1):259-268. PMC: 10774153. DOI: 10.1007/s00402-023-05073-9. View

5.
Berkes M, Obremskey W, Scannell B, Ellington J, Hymes R, Bosse M . Maintenance of hardware after early postoperative infection following fracture internal fixation. J Bone Joint Surg Am. 2010; 92(4):823-8. DOI: 10.2106/JBJS.I.00470. View