Alcohol Consumption During Pregnancy Differentially Affects the Fecal Microbiota of Dams and Offspring

Overview

Journal Sci Rep

Specialty Science

Date 2024 Jul 12

PMID 38997303

Authors

Tamara S Bodnar

Garrett Ainsworth-Cruickshank

Vincent Billy

Laura Wegener Parfrey

Joanne Weinberg

Charlis Raineki

Affiliations

Soon will be listed here.

Abstract

Microbiota imbalances are linked to inflammation and disease, as well as neurodevelopmental conditions where they may contribute to behavioral, physiological, and central nervous system dysfunction. By contrast, the role of the microbiota in Fetal Alcohol Spectrum Disorder (FASD), the group of neurodevelopmental conditions that can occur following prenatal alcohol exposure (PAE), has not received similar attention. Here we utilized a rodent model of alcohol consumption during pregnancy to characterize the impact of alcohol on the microbiota of dam-offspring dyads. Overall, bacterial diversity decreased in alcohol-consuming dams and community composition differed from that of controls in alcohol-consuming dams and their offspring. Bacterial taxa and predicted biochemical pathway composition were also altered with alcohol consumption/exposure; however, there was minimal overlap between the changes in dams and offspring. These findings illuminate the potential importance of the microbiota in the pathophysiology of FASD and support investigation into novel microbiota-based interventions.

Citing Articles

Prenatal Stress and Ethanol Exposure: Microbiota-Induced Immune Dysregulation and Psychiatric Risks.

Camarini R, Marianno P, Hanampa-Maquera M, Oliveira S, Camara N Int J Mol Sci. 2024; 25(18).

PMID: 39337263 PMC: 11431796. DOI: 10.3390/ijms25189776.

References

Hollister E, Riehle K, Luna R, Weidler E, Rubio-Gonzales M, Mistretta T . Structure and function of the healthy pre-adolescent pediatric gut microbiome. Microbiome. 2015; 3:36. PMC: 4550057. DOI: 10.1186/s40168-015-0101-x. View

Kelly C, Zheng L, Campbell E, Saeedi B, Scholz C, Bayless A . Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function. Cell Host Microbe. 2015; 17(5):662-71. PMC: 4433427. DOI: 10.1016/j.chom.2015.03.005. View

Hillemacher T, Bachmann O, Kahl K, Frieling H . Alcohol, microbiome, and their effect on psychiatric disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2018; 85:105-115. DOI: 10.1016/j.pnpbp.2018.04.015. View

Comeau A, Douglas G, Langille M . Microbiome Helper: a Custom and Streamlined Workflow for Microbiome Research. mSystems. 2017; 2(1). PMC: 5209531. DOI: 10.1128/mSystems.00127-16. View

Cryan J, Dinan T . Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci. 2012; 13(10):701-12. DOI: 10.1038/nrn3346. View

Haycock P . Fetal alcohol spectrum disorders: the epigenetic perspective. Biol Reprod. 2009; 81(4):607-17. DOI: 10.1095/biolreprod.108.074690. View

Zietek M, Celewicz Z, Szczuko M . Short-Chain Fatty Acids, Maternal Microbiota and Metabolism in Pregnancy. Nutrients. 2021; 13(4). PMC: 8069164. DOI: 10.3390/nu13041244. View

Mellon A, Deshpande S, Mathers J, Bartlett K . Effect of oral antibiotics on intestinal production of propionic acid. Arch Dis Child. 2000; 82(2):169-72. PMC: 1718213. DOI: 10.1136/adc.82.2.169. View

Zeng M, Inohara N, Nunez G . Mechanisms of inflammation-driven bacterial dysbiosis in the gut. Mucosal Immunol. 2016; 10(1):18-26. PMC: 5788567. DOI: 10.1038/mi.2016.75. View

10.

Kuprys P, Cannon A, Shieh J, Iftekhar N, Park S, Eberhardt J . Alcohol decreases intestinal ratio of to and induces hepatic immune tolerance in a murine model of DSS-colitis. Gut Microbes. 2020; 12(1):1-16. PMC: 7671045. DOI: 10.1080/19490976.2020.1838236. View

11.

Flemer B, Gaci N, Borrel G, Sanderson I, Chaudhary P, Tottey W . Fecal microbiota variation across the lifespan of the healthy laboratory rat. Gut Microbes. 2017; 8(5):428-439. PMC: 5628645. DOI: 10.1080/19490976.2017.1334033. View

12.

Schloss P, Schubert A, Zackular J, Iverson K, Young V, Petrosino J . Stabilization of the murine gut microbiome following weaning. Gut Microbes. 2012; 3(4):383-93. PMC: 3463496. DOI: 10.4161/gmic.21008. View

13.

Nearing J, Douglas G, Hayes M, MacDonald J, Desai D, Allward N . Microbiome differential abundance methods produce different results across 38 datasets. Nat Commun. 2022; 13(1):342. PMC: 8763921. DOI: 10.1038/s41467-022-28034-z. View

14.

Jakobsson H, Rodriguez-Pineiro A, Schutte A, Ermund A, Boysen P, Bemark M . The composition of the gut microbiota shapes the colon mucus barrier. EMBO Rep. 2014; 16(2):164-77. PMC: 4328744. DOI: 10.15252/embr.201439263. View

15.

Lebeer S, Vanderleyden J, de Keersmaecker S . Genes and molecules of lactobacilli supporting probiotic action. Microbiol Mol Biol Rev. 2008; 72(4):728-64, Table of Contents. PMC: 2593565. DOI: 10.1128/MMBR.00017-08. View

16.

Naseribafrouei A, Hestad K, Avershina E, Sekelja M, Linlokken A, Wilson R . Correlation between the human fecal microbiota and depression. Neurogastroenterol Motil. 2014; 26(8):1155-62. DOI: 10.1111/nmo.12378. View

17.

Bangsgaard Bendtsen K, Krych L, Sorensen D, Pang W, Nielsen D, Josefsen K . Gut microbiota composition is correlated to grid floor induced stress and behavior in the BALB/c mouse. PLoS One. 2012; 7(10):e46231. PMC: 3462757. DOI: 10.1371/journal.pone.0046231. View

18.

Tochitani S . Vertical transmission of gut microbiota: Points of action of environmental factors influencing brain development. Neurosci Res. 2020; 168:83-94. DOI: 10.1016/j.neures.2020.11.006. View

19.

Wang Y, Xie T, Wu Y, Liu Y, Zou Z, Bai J . Impacts of Maternal Diet and Alcohol Consumption during Pregnancy on Maternal and Infant Gut Microbiota. Biomolecules. 2021; 11(3). PMC: 8001387. DOI: 10.3390/biom11030369. View

20.

Engen P, Green S, Voigt R, Forsyth C, Keshavarzian A . The Gastrointestinal Microbiome: Alcohol Effects on the Composition of Intestinal Microbiota. Alcohol Res. 2015; 37(2):223-36. PMC: 4590619. View