Pharmacokinetics of an Extended-release Dosage Form of Molsidomine in Patients with Coronary Heart Disease

Overview

Journal Eur J Clin Pharmacol

Specialty Pharmacology

Date 1985 Jan 1

PMID 3899679

Citations 2

Authors

J Ostrowski

G Gaul

D Voegele

D Brockmeier

K RESAG

Affiliations

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Abstract

Molsidomine (N-carboxy-3-morpholino-sydnonimine-ethylester; Cassella-Riedel Pharma GmbH, Frankfurt/M. FRG) has an antianginal effect for up to 3-5 h after oral administration of 2 mg Corvaton [1]. Plasma levels of the parent drug can be measured during this interval. A new galenic formulation (Corvaton retard) has been developed to prolong the duration of the therapeutic action and to improve patient compliance. The present study was carried out to establish whether the in vitro dissolution profile of the tablet was reflected in vivo, thus permitting prediction of plasma molsidomine levels in patients with coronary heart disease.

Citing Articles

A pilot double-blind randomized placebo-controlled study of molsidomine 16 mg once-a-day in patients suffering from stable angina pectoris: correlation between efficacy and over time plasma concentrations.

Messin R, Fenyvesi T, Carreer-Bruhwyler F, Crommen J, Chiap P, Hubert P Eur J Clin Pharmacol. 2003; 59(3):227-32.

PMID: 12734607 DOI: 10.1007/s00228-003-0597-z.

Clinical pharmacokinetics of vasodilators. Part II.

Kirsten R, Nelson K, Kirsten D, Heintz B Clin Pharmacokinet. 1998; 35(1):9-36.

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References

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