The Impact of Consanguinity on the Design of IPSC Banks

Overview

Journal Stem Cell Reports

Publisher Cell Press

Specialty Cell Biology

Date 2024 Jul 12

PMID 38996491

Authors

Imen F Alkuraya

Edward B De Vol

Affiliations

Soon will be listed here.

Abstract

The effect of consanguinity on identifying universal induced pluripotent stem cell (iPSC) donors, i.e., homozygous for the major human leukocyte antigen (HLA) loci, is unknown. The discovery sample size was calculated in a consanguineous population using a method (1qF) based on the inbreeding coefficient. The result was orders of magnitude smaller compared to the standard method.

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