Impacts Epithelial Turnover and is Resistant to Induced Death of the Host Cell

Overview

Journal mBio

Publisher American Society for Microbiology

Specialty Microbiology

Date 2024 Jul 12

PMID 38995074

Authors

Bethan A Wallbank

Ryan D Pardy

Igor E Brodsky

Christopher A Hunter

Boris Striepen

Affiliations

Soon will be listed here.

Abstract

Importance: The intestine must balance its roles in digestion and nutrient absorption with the maintenance of an effective barrier to colonization and breach by numerous potential pathogens. An important component of this balance is its constant turnover, which is modulated by a gain of cells due to proliferation and loss due to death or extrusion. Here, we report that infection changes the dynamics of this process increasing both gain and loss of enterocytes speeding up the villus elevator. This leads to a much more immature epithelium and a reduction of the number of those cells typically found toward the villus apex best equipped to take up key nutrients including carbohydrates and lipids. These changes in the cellular architecture and physiology of the small intestine may be linked to the profound association between cryptosporidiosis and malnutrition.

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