Spatio-Temporal Regulation of Notch Activation in Asymmetrically Dividing Sensory Organ Precursor Cells in Epithelium

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2024 Jul 12

PMID 38994985

Authors

Mathieu Pinot

Roland Le Borgne

Affiliations

Soon will be listed here.

Abstract

The Notch communication pathway, discovered in over 100 years ago, regulates a wide range of intra-lineage decisions in metazoans. The division of the mechanosensory organ precursor is the archetype of asymmetric cell division in which differential Notch activation takes place at cytokinesis. Here, we review the molecular mechanisms by which epithelial cell polarity, cell cycle and intracellular trafficking participate in controlling the directionality, subcellular localization and temporality of mechanosensitive Notch receptor activation in cytokinesis.

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