Therapeutic Effect of San Bi Tang Combined with Glucosamine Sulfate Capsules in Cold-dampness-type Knee Osteoarthritis

Overview

Journal World J Clin Cases

Publisher Baishideng Publishing Group

Specialty General Medicine

Date 2024 Jul 12

PMID 38994299

Authors

Hui-Ying Ni

Yao-Ping Zhang

Xiao-Feng Zhang

Affiliations

Soon will be listed here.

Abstract

Background: Cold-dampness-type knee osteoarthritis is a common middle-aged and elderly disease, but its pathogenesis is not fully understood, and its clinical treatment has limitations. Glucosamine sulfate capsules are commonly used for treating arthritis, and San Bi Tang is a classic formula of traditional Chinese medicine (TCM) that has the effects of warming yang, dispelling dampness, relaxing muscles, and activating collaterals. This research hypothesized that the combination of modified San Bi Tang and glucosamine sulfate capsules could enhance the clinical efficacy of treating cold-dampness-type knee osteoarthritis through complementary effects.

Aim: To analyze the clinical efficacy of San Bi Tang combined with glucosamine sulfate capsules when treating cold-dampness-type knee osteoarthritis.

Methods: A total of 110 patients with cold-dampness-type knee osteoarthritis were selected as research subjects and randomly divided into a control group and an experimental group of 55 cases each. The control group received only treatment with glucosamine sulfate capsules, while the experimental group received additional treatment with modified San Bi Tang for a duration of 5 wk. The patients' knee joint functions, liver and kidney function indicators, adverse reactions, and vital signs were evaluated and analyzed using SPSS 26.0 software.

Results: Before treatment, the two groups' genders, ages, and scores were not significantly different, indicating comparability. Both groups' scores improved after treatment, which could indicate pain and knee joint function improvement, but the test group had better scores. The TCM-specific symptoms and the clinical efficacy of the treatment in the test group were higher. Before and after treatment, there were no abnormalities in the patients' liver and kidney function indicators.

Conclusion: The combination of modified San Bi Tang and glucosamine sulfate capsules is superior to treatment with sulfated glucosamine alone and has high safety.

References

Saleki M, Ahadi T, Razi M, Raeisi G, Forough B, Ali M . Comparison of the effects of acupuncture and isometric exercises on symptom of knee osteoarthritis. Int J Prev Med. 2013; 4(Suppl 1):S73-7. PMC: 3665031. View

Veronese N, Ecarnot F, Cheleschi S, Fioravanti A, Maggi S . Possible synergic action of non-steroidal anti-inflammatory drugs and glucosamine sulfate for the treatment of knee osteoarthritis: a scoping review. BMC Musculoskelet Disord. 2022; 23(1):1084. PMC: 9743630. DOI: 10.1186/s12891-022-06046-6. View

Ytterberg S, Bhatt D, Mikuls T, Koch G, Fleischmann R, Rivas J . Cardiovascular and Cancer Risk with Tofacitinib in Rheumatoid Arthritis. N Engl J Med. 2022; 386(4):316-326. DOI: 10.1056/NEJMoa2109927. View

Sanchez-Lopez E, Coras R, Torres A, Lane N, Guma M . Synovial inflammation in osteoarthritis progression. Nat Rev Rheumatol. 2022; 18(5):258-275. PMC: 9050956. DOI: 10.1038/s41584-022-00749-9. View

Arden N, Perry T, Bannuru R, Bruyere O, Cooper C, Haugen I . Non-surgical management of knee osteoarthritis: comparison of ESCEO and OARSI 2019 guidelines. Nat Rev Rheumatol. 2020; 17(1):59-66. DOI: 10.1038/s41584-020-00523-9. View

Whittaker J, Runhaar J, Bierma-Zeinstra S, Roos E . A lifespan approach to osteoarthritis prevention. Osteoarthritis Cartilage. 2021; 29(12):1638-1653. DOI: 10.1016/j.joca.2021.06.015. View

Quicke J, Conaghan P, Corp N, Peat G . Osteoarthritis year in review 2021: epidemiology & therapy. Osteoarthritis Cartilage. 2021; 30(2):196-206. DOI: 10.1016/j.joca.2021.10.003. View

Jiang Y . Osteoarthritis year in review 2021: biology. Osteoarthritis Cartilage. 2021; 30(2):207-215. DOI: 10.1016/j.joca.2021.11.009. View

Zhang H, Cai D, Bai X . Macrophages regulate the progression of osteoarthritis. Osteoarthritis Cartilage. 2020; 28(5):555-561. DOI: 10.1016/j.joca.2020.01.007. View

10.

Whittaker J, Truong L, Dhiman K, Beck C . Osteoarthritis year in review 2020: rehabilitation and outcomes. Osteoarthritis Cartilage. 2020; 29(2):190-207. DOI: 10.1016/j.joca.2020.10.005. View

11.

Sharma L . Osteoarthritis of the Knee. N Engl J Med. 2021; 384(1):51-59. DOI: 10.1056/NEJMcp1903768. View

12.

Aubourg G, Rice S, Bruce-Wootton P, Loughlin J . Genetics of osteoarthritis. Osteoarthritis Cartilage. 2021; 30(5):636-649. PMC: 9067452. DOI: 10.1016/j.joca.2021.03.002. View

13.

Allen K, Thoma L, Golightly Y . Epidemiology of osteoarthritis. Osteoarthritis Cartilage. 2021; 30(2):184-195. PMC: 10735233. DOI: 10.1016/j.joca.2021.04.020. View

14.

Lawford B, Bennell K, Hall M, Egerton T, Filbay S, McManus F . Removing Pathoanatomical Content From Information Pamphlets About Knee Osteoarthritis Did Not Affect Beliefs About Imaging or Surgery, but Led to Lower Perceptions That Exercise Is Damaging and Better Osteoarthritis Knowledge: An Online Randomised.... J Orthop Sports Phys Ther. 2022; 53(4):202-216. DOI: 10.2519/jospt.2022.11618. View

15.

Hunter D, March L, Chew M . Osteoarthritis in 2020 and beyond: a Lancet Commission. Lancet. 2020; 396(10264):1711-1712. DOI: 10.1016/S0140-6736(20)32230-3. View

16.

Holden M, Nicolson P, Thomas M, Corp N, Hinman R, Bennell K . Osteoarthritis year in review 2022: rehabilitation. Osteoarthritis Cartilage. 2022; 31(2):177-186. DOI: 10.1016/j.joca.2022.10.004. View

17.

Deane K, Holers V . Rheumatoid Arthritis Pathogenesis, Prediction, and Prevention: An Emerging Paradigm Shift. Arthritis Rheumatol. 2020; 73(2):181-193. PMC: 7772259. DOI: 10.1002/art.41417. View

18.

Richard M, Driban J, McAlindon T . Pharmaceutical treatment of osteoarthritis. Osteoarthritis Cartilage. 2022; 31(4):458-466. DOI: 10.1016/j.joca.2022.11.005. View

19.

Katz J, Arant K, Loeser R . Diagnosis and Treatment of Hip and Knee Osteoarthritis: A Review. JAMA. 2021; 325(6):568-578. PMC: 8225295. DOI: 10.1001/jama.2020.22171. View