Tregs in Transplantation Tolerance: Role and Therapeutic Potential

Overview

Journal Front Transplant

Specialty General Surgery

Date 2024 Jul 12

PMID 38993904

Authors

Alexandra Cassano

Anita S Chong

Maria-Luisa Alegre

Affiliations

Soon will be listed here.

Abstract

CD4 Foxp3 regulatory T cells (Tregs) are indispensable for preventing autoimmunity, and they play a role in cancer and transplantation settings by restraining immune responses. In this review, we describe evidence for the importance of Tregs in the induction versus maintenance of transplantation tolerance, discussing insights into mechanisms of Treg control of the alloimmune response. Further, we address the therapeutic potential of Tregs as a clinical intervention after transplantation, highlighting engineered CAR-Tregs as well as expansion of donor and host Tregs.

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