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A Treatment Within Sight: Challenges in the Development of Stem Cell-derived Photoreceptor Therapies for Retinal Degenerative Diseases

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Specialty General Surgery
Date 2024 Jul 12
PMID 38993872
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Abstract

Stem cell therapies can potentially treat various retinal degenerative diseases, including age-related macular degeneration (AMD) and inherited retinal diseases like retinitis pigmentosa. For these diseases, transplanted cells may include stem cell-derived retinal pigmented epithelial (RPE) cells, photoreceptors, or a combination of both. Although stem cell-derived RPE cells have progressed to human clinical trials, therapies using photoreceptors and other retinal cell types are lagging. In this review, we discuss the potential use of human pluripotent stem cell (hPSC)-derived photoreceptors for the treatment of retinal degeneration and highlight the progress and challenges for their efficient production and clinical application in regenerative medicine.

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References
1.
Pittack C, Grunwald G, Reh T . Fibroblast growth factors are necessary for neural retina but not pigmented epithelium differentiation in chick embryos. Development. 1997; 124(4):805-16. DOI: 10.1242/dev.124.4.805. View

2.
Turner J, Blair J . Newborn rat retinal cells transplanted into a retinal lesion site in adult host eyes. Brain Res. 1986; 391(1):91-104. DOI: 10.1016/0165-3806(86)90011-8. View

3.
Cerro M, Notter M, del Cerro C, Wiegand S, Grover D, Lazar E . Intraretinal transplantation for rod-cell replacement in light-damaged retinas. J Neural Transplant. 1989; 1(1):1-10. PMC: 2564997. DOI: 10.1155/NP.1989.1. View

4.
Liao D, Metlapally R, Joshi P . Pegcetacoplan treatment for geographic atrophy due to age-related macular degeneration: a plain language summary of the FILLY study. Immunotherapy. 2022; 14(13):995-1006. DOI: 10.2217/imt-2022-0078. View

5.
Schwartz S, Hubschman J, Heilwell G, Franco-Cardenas V, Pan C, Ostrick R . Embryonic stem cell trials for macular degeneration: a preliminary report. Lancet. 2012; 379(9817):713-20. DOI: 10.1016/S0140-6736(12)60028-2. View