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Can Hyperthermia Unveil Brugada Pattern?

Overview
Journal J Med Cases
Specialty General Medicine
Date 2024 Jul 12
PMID 38993811
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Abstract

Brugada syndrome (BrS) is characterized by ST segment elevations in the right precordial leads, V1 - V3, with additional findings of ventricular arrhythmias and family history (FH) of sudden cardiac death (SCD) at a young age. Here, we describe a case of hyperthermia, unveiling the Brugada electrocardiography (EKG) pattern and the resolution of EKG findings with appropriate hyperthermia management. It is important to distinguish the Brugada EKG pattern from other causes of ST elevations and treat appropriately to prevent patients from developing ventricular fibrillation and SCD. It is key to identify environmental triggers in patients presenting with Brugada EKG pattern and closely monitor for ventricular fibrillation. Educating patients on prompt fever treatment with antipyretics and avoiding medications like sodium channel blockers during the febrile event is paramount to counter patients going into ventricular fibrillation. It is also crucial for close follow-up of these patients, offering them genetic testing for BrS and screening families of patients with BrS.

Citing Articles

Causal Relationship Between Electrocardiogram Parameters and Brugada Syndrome: A Bidirectional Mendelian Randomization Study.

Shen S, Wang X, Huang J, Li W Ann Noninvasive Electrocardiol. 2025; 30(2):e70060.

PMID: 40070266 PMC: 11897611. DOI: 10.1111/anec.70060.

References
1.
Priori S, Wilde A, Horie M, Cho Y, Behr E, Berul C . HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes: document endorsed by HRS, EHRA, and APHRS in May 2013 and by ACCF, AHA, PACES, and AEPC in June 2013. Heart Rhythm. 2013; 10(12):1932-63. DOI: 10.1016/j.hrthm.2013.05.014. View

2.
Morita H, Zipes D, Morita S, Wu J . Temperature modulation of ventricular arrhythmogenicity in a canine tissue model of Brugada syndrome. Heart Rhythm. 2007; 4(2):188-97. DOI: 10.1016/j.hrthm.2006.10.015. View

3.
Sarquella-Brugada G, Campuzano O, Arbelo E, Brugada J, Brugada R . Brugada syndrome: clinical and genetic findings. Genet Med. 2015; 18(1):3-12. DOI: 10.1038/gim.2015.35. View

4.
Li Y, Lang S, Akin I, Zhou X, El-Battrawy I . Brugada Syndrome: Different Experimental Models and the Role of Human Cardiomyocytes From Induced Pluripotent Stem Cells. J Am Heart Assoc. 2022; 11(7):e024410. PMC: 9075459. DOI: 10.1161/JAHA.121.024410. View

5.
Ackerman M, Priori S, Willems S, Berul C, Brugada R, Calkins H . HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies this document was developed as a partnership between the Heart Rhythm Society (HRS) and the European Heart Rhythm Association (EHRA). Heart Rhythm. 2011; 8(8):1308-39. DOI: 10.1016/j.hrthm.2011.05.020. View