Effect of Time-restricted Eating Regimen on Weight Loss is Mediated by Gut Microbiome

Overview

Journal iScience

Publisher Cell Press

Date 2024 Jul 12

PMID 38993674

Authors

Chensihan Huang

Deying Liu

Shunyu Yang

Yan Huang

Xueyun Wei

Peizhen Zhang

Jiayang Lin

Bingyan Xu

Yating Liu

Dan Guo

Yafeng Li

Jin Li

Huijie Zhang

Affiliations

Soon will be listed here.

Abstract

Time-restricted eating (TRE) is a promising obesity management strategy, but weight-loss efficacy varies among participants, and the underlying mechanism is unclear. The study aimed to investigate the role of gut microbiota in weight-loss response during long-term TRE intervention. We analyzed data from 51 obese adults in a 12-month TRE program, categorizing them into distinct weight loss groups (DG) and moderate weight loss groups (MG) based on their TRE responses. Shotgun metagenomic sequencing analysis revealed a significant increase in species closely associated with weight loss effectiveness and metabolic parameter changes in the DG group. Pathways related to fatty acid biosynthesis, glycogen biosynthesis, and nucleotide metabolism were reduced in the DG group and enhanced in the MG group. Next, we identified nine specific species at baseline that contributed better responses to TRE intervention and significant weight loss. Collectively, gut microbiota contributes to responsiveness heterogeneity in TRE and can predict weight-loss effectiveness.

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