Self-assembled Nanoparticles of Costunolide and Glycyrrhizic Acid for Enhanced Ulcerative Colitis Treatment

Overview

Journal BMC Gastroenterol

Publisher Biomed Central

Specialty Gastroenterology

Date 2024 Jul 11

PMID 38992591

Authors

Hao Fu

Xiao Zheng

Ke Xu

Yuge Zhang

Mengxia Wu

Min Xu

Affiliations

Soon will be listed here.

Abstract

Ulcerative colitis (UC) is a persistent inflammatory condition that specifically targets the colon and rectum. Existing therapies fail to adequately address the clinical requirements of people suffering from this ailment. Despite the acknowledged potential of nanomedicines in the field of anti-inflammatory treatment, their widespread use in clinical settings is impeded by their expensive nature and the uncertainty surrounding their safety profiles. This study illustrates that two naturally occurring phytochemicals, Costunolide (COS) and Glycyrrhizic acid (GA), form carrier-free, multifunctional spherical nanoparticles (NPs) through noncovalent interactions, such as π-π stacking and hydrogen bonding. The COS-GA NPs displayed a synergistic anti-inflammatory effect, providing much more evidently improved therapeutic benefits for dextran sodium sulfate (DSS)-induced UC mice due to more effective reduction in inflammation and oxidative stress than did equal dosages of COS or GA used alone. In addition, COS-GA NPs have biocompatibility and biosafety properties unique to them. This study will serve as affirmation of the potential of COS-GA NPs as innovative natural anti-inflammatory and antioxidant activities and also such agents as drug discovery in UC, leading possibly to better outcomes in people living with this disabling condition.

References

Haifer C, Paramsothy S, Kaakoush N, Saikal A, Ghaly S, Yang T . Lyophilised oral faecal microbiota transplantation for ulcerative colitis (LOTUS): a randomised, double-blind, placebo-controlled trial. Lancet Gastroenterol Hepatol. 2021; 7(2):141-151. DOI: 10.1016/S2468-1253(21)00400-3. View

Almalik A, Alradwan I, Kalam M, Alshamsan A . Effect of cryoprotection on particle size stability and preservation of chitosan nanoparticles with and without hyaluronate or alginate coating. Saudi Pharm J. 2017; 25(6):861-867. PMC: 5605945. DOI: 10.1016/j.jsps.2016.12.008. View

Trenkenschuh E, Friess W . Freeze-thaw stability of aluminum oxide nanoparticles. Int J Pharm. 2021; 606:120932. DOI: 10.1016/j.ijpharm.2021.120932. View

Guo H, Zhang J, Gao W, Qu Z, Liu C . Gastrointestinal effect of methanol extract of Radix Aucklandiae and selected active substances on the transit activity of rat isolated intestinal strips. Pharm Biol. 2014; 52(9):1141-9. DOI: 10.3109/13880209.2013.879601. View

Shen C, Shen B, Zhu J, Wang J, Yuan H, Li X . Glycyrrhizic acid-based self-assembled micelles for improving oral bioavailability of paeoniflorin. Drug Dev Ind Pharm. 2020; 47(2):207-214. DOI: 10.1080/03639045.2020.1862178. View

Xie F, Zhang H, Zheng C, Shen X . Costunolide improved dextran sulfate sodium-induced acute ulcerative colitis in mice through NF-κB, STAT1/3, and Akt signaling pathways. Int Immunopharmacol. 2020; 84:106567. DOI: 10.1016/j.intimp.2020.106567. View

Hou Y, Wang H, Zhang F, Sun F, Xin M, Li M . Novel self-nanomicellizing solid dispersion based on rebaudioside A: a potential nanoplatform for oral delivery of curcumin. Int J Nanomedicine. 2019; 14:557-571. PMC: 6333391. DOI: 10.2147/IJN.S191337. View

Qin Z, Li M, Cheng J, Huang Z, Ai G, Qu C . Self-Assembled nanoparticles Combining Berberine and Sodium Taurocholate for Enhanced Anti-Hyperuricemia Effect. Int J Nanomedicine. 2023; 18:4101-4120. PMC: 10387259. DOI: 10.2147/IJN.S409513. View

Murano M, Maemura K, Hirata I, Toshina K, Nishikawa T, Hamamoto N . Therapeutic effect of intracolonically administered nuclear factor kappa B (p65) antisense oligonucleotide on mouse dextran sulphate sodium (DSS)-induced colitis. Clin Exp Immunol. 2000; 120(1):51-8. PMC: 1905625. DOI: 10.1046/j.1365-2249.2000.01183.x. View

10.

You G, Feng T, Zhang G, Chen M, Liu F, Sun L . Preparation, optimization, characterization and in vitro release of baicalein-solubilizing glycyrrhizic acid nano-micelles. Int J Pharm. 2021; 601:120546. DOI: 10.1016/j.ijpharm.2021.120546. View

11.

Sultana S, AlZahrani N, Alzahrani R, Alshamrani W, Aloufi W, Ali A . Stability issues and approaches to stabilised nanoparticles based drug delivery system. J Drug Target. 2020; 28(5):468-486. DOI: 10.1080/1061186X.2020.1722137. View

12.

Gao S, Zheng H, Xu S, Kong J, Gao F, Wang Z . Novel Natural Carrier-Free Self-Assembled Nanoparticles for Treatment of Ulcerative Colitis by Balancing Immune Microenvironment and Intestinal Barrier. Adv Healthc Mater. 2023; 12(31):e2301826. DOI: 10.1002/adhm.202301826. View

13.

Yusuf A, Almotairy A, Henidi H, Alshehri O, Aldughaim M . Nanoparticles as Drug Delivery Systems: A Review of the Implication of Nanoparticles' Physicochemical Properties on Responses in Biological Systems. Polymers (Basel). 2023; 15(7). PMC: 10096782. DOI: 10.3390/polym15071596. View

14.

Wu X, Zhang Q, Peng L, Tian Z, Gou G, Zuo W . Colon-targeted piperine-glycyrrhizic acid nanocrystals for ulcerative colitis synergetic therapy macrophage polarization. J Mater Chem B. 2024; 12(6):1604-1616. DOI: 10.1039/d3tb02312e. View

15.

Cui L, Guan X, Ding W, Luo Y, Wang W, Bu W . Scutellaria baicalensis Georgi polysaccharide ameliorates DSS-induced ulcerative colitis by improving intestinal barrier function and modulating gut microbiota. Int J Biol Macromol. 2020; 166:1035-1045. DOI: 10.1016/j.ijbiomac.2020.10.259. View

16.

Dou Y, Zhou J, Wang T, Huang Y, Chen V, Xie Y . Self-nanoemulsifying drug delivery system of bruceine D: a new approach for anti-ulcerative colitis. Int J Nanomedicine. 2018; 13:5887-5907. PMC: 6167998. DOI: 10.2147/IJN.S174146. View

17.

Wan Z, Sun Y, Ma L, Guo J, Wang J, Yin S . Thermoresponsive structured emulsions based on the fibrillar self-assembly of natural saponin glycyrrhizic acid. Food Funct. 2016; 8(1):75-85. DOI: 10.1039/c6fo01485b. View

18.

Kaszuba M, Corbett J, Watson F, Jones A . High-concentration zeta potential measurements using light-scattering techniques. Philos Trans A Math Phys Eng Sci. 2010; 368(1927):4439-51. PMC: 2981904. DOI: 10.1098/rsta.2010.0175. View

19.

Alhakamy N, Badr-Eldin S, Ahmed O, Aldawsari H, Okbazghi S, Alfaleh M . Green Nanoemulsion Stabilized by In Situ Self-Assembled Natural Oil/Native Cyclodextrin Complexes: An Eco-Friendly Approach for Enhancing Anticancer Activity of Costunolide against Lung Cancer Cells. Pharmaceutics. 2022; 14(2). PMC: 8880633. DOI: 10.3390/pharmaceutics14020227. View

20.

Wu A, Chen C, Lu J, Sun J, Xiao M, Yue X . Preparation of Oral Core-Shell Zein Nanoparticles to Improve the Bioavailability of Glycyrrhizic Acid for the Treatment of Ulcerative Colitis. Biomacromolecules. 2021; 23(1):210-225. DOI: 10.1021/acs.biomac.1c01233. View