Formation and Resolution of Meiotic Chromosome Entanglements and Interlocks

Overview

Journal J Cell Sci

Specialty Cell Biology

Date 2024 Jul 10

PMID 38985540

Authors

Ivan Olaya

Sean M Burgess

Ofer Rog

Affiliations

Soon will be listed here.

Abstract

Interactions between parental chromosomes during the formation of gametes can lead to entanglements, entrapments and interlocks between unrelated chromosomes. If unresolved, these topological constraints can lead to misregulation of exchanges between chromosomes and to chromosome mis-segregation. Interestingly, these configurations are largely resolved by the time parental chromosomes are aligned during pachytene. In this Review, we highlight the inevitability of topologically complex configurations and discuss possible mechanisms to resolve them. We focus on the dynamic nature of a conserved chromosomal interface - the synaptonemal complex - and the chromosome movements that accompany meiosis as potential mechanisms to resolve topological constraints. We highlight the advantages of the nematode Caenorhabditis elegans for understanding biophysical features of the chromosome axis and synaptonemal complex that could contribute to mechanisms underlying interlock resolution. In addition, we highlight advantages of using the zebrafish, Danio rerio, as a model to understand how entanglements and interlocks are avoided and resolved.

Citing Articles

Synaptonemal complex protects double-Holliday junctions during meiosis.

Tang S, Koo J, Pourhosseinzadeh M, Nguyen E, Liu N, Ma C bioRxiv. 2024; .

PMID: 39314413 PMC: 11419148. DOI: 10.1101/2024.09.14.613089.

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