Reconsidering the Role of Depression and Common Psychiatric Disorders As Partners in the Type 2 Diabetes Epidemic

Overview

Journal World J Diabetes

Publisher Baishideng Publishing Group

Specialty Endocrinology

Date 2024 Jul 10

PMID 38983820

Authors

Angelo Emilio Claro

Clelia Palanza

Marianna Mazza

Alessandro Rizzi

Andrea Corsello

Linda Tartaglione

Giuseppe Marano

Giovanna Elsa Ute Muti Schuenemann

Marta Rigoni

Alfredo Pontecorvi

Luigi Janiri

Paola Muti

Dario Pitocco

Affiliations

Soon will be listed here.

Abstract

Common psychiatric disorders (CPDs) and depression contribute significantly to the global epidemic of type 2 diabetes (T2D). We postulated a possible pathophysiological mechanism that through Bridge-Symptoms present in depression and CPDs, promotes the establishment of emotional eating, activation of the reward system, onset of overweight and obesity and, ultimately the increased risk of developing T2D. The plausibility of the proposed pathophysiological mechanism is supported by the mechanism of action of drugs such as naltrexone-bupropion currently approved for the treatment of both obesity/overweight with T2D and as separate active pharmaceutical ingredients in drug addiction, but also from initial evidence that is emerging regarding glucagon-like peptide 1 receptor agonists that appear to be effective in the treatment of drug addiction. We hope that our hypothesis may be useful in interpreting the higher prevalence of CPDs and depression in patients with T2D compared with the general population and may help refine the integrated psychiatric-diabetic therapy approach to improve the treatment and or remission of T2D.

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