» Articles » PMID: 38983710

Therapeutic Myths in Solid Organ Transplantation Infectious Diseases

Abstract

Infection management in solid organ transplantation poses unique challenges, with a diverse array of potential pathogens and associated antimicrobial therapies. With limited high-quality randomized clinical trials to direct optimal care, therapeutic "myths" may propagate and contribute to suboptimal or excessive antimicrobial use. We discuss 6 therapeutic myths with particular relevance to solid organ transplantation and provide recommendations for infectious diseases clinicians involved in the care of this high-risk population.

References
1.
Limaye A, Budde K, Humar A, Vincenti F, Kuypers D, Carroll R . Letermovir vs Valganciclovir for Prophylaxis of Cytomegalovirus in High-Risk Kidney Transplant Recipients: A Randomized Clinical Trial. JAMA. 2023; 330(1):33-42. PMC: 10245286. DOI: 10.1001/jama.2023.9106. View

2.
Hirsch H, Randhawa P . BK polyomavirus in solid organ transplantation-Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. Clin Transplant. 2019; 33(9):e13528. DOI: 10.1111/ctr.13528. View

3.
Al Jurdi A, Gassen R, Borges T, Solhjou Z, Hullekes F, Lape I . Non-Invasive Monitoring for Rejection in Kidney Transplant Recipients After SARS-CoV-2 mRNA Vaccination. Front Immunol. 2022; 13:838985. PMC: 8913529. DOI: 10.3389/fimmu.2022.838985. View

4.
Martin J, Dvorak C, Smee D, Matthews T, Verheyden J . 9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine: a new potent and selective antiherpes agent. J Med Chem. 1983; 26(5):759-61. DOI: 10.1021/jm00359a023. View

5.
Krantz M, Stone Jr C, Abreo A, Phillips E . Oral challenge with trimethoprim-sulfamethoxazole in patients with "sulfa" antibiotic allergy. J Allergy Clin Immunol Pract. 2019; 8(2):757-760.e4. PMC: 6960372. DOI: 10.1016/j.jaip.2019.07.003. View