Clinical Outcomes of Ablation of Gastric Dysplasia with Argon Plasma Coagulation

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2024 Jul 9

PMID 38980853

Authors

Mi Jin Oh

Sang Gyun Kim

Jiyoon Kim

Yun Suk Na

Seunghan Lee

Junhee Lee

Bokyung Kim

Hyunsoo Chung

Soo-Jeong Cho

Affiliations

Soon will be listed here.

Abstract

Background: Although several small cohort studies have shown the utility of argon plasma coagulation (APC) in the treatment of gastric dysplasia, its clinical significance has not been established. This study aims to assess the efficacy of APC as a first line treatment for gastric dysplasia, and identify risk factors for residual dysplasia.

Methods: A total of 179 cases of gastric dysplasia were treated with APC and have been followed-up with upper endoscopy within 1 year. The overall incidence and the characteristics of lesions with residual dysplasia in follow-up endoscopy were analyzed by logistic regression.

Results: Among 179 lesions treated with APC, 171 (95.5%) lesions have achieved complete ablation in the follow-up endoscopy. Additional APC was applied for residual dysplasia, achieving complete ablation in 97.77% (175/179). The upper third location of the gastric dysplasia was significantly associated with residual dysplasia, while tumor size, horizontal location, macroscopic morphology and grade of dysplasia showed no significant associations with residual dysplasia following the initial APC.

Conclusions: APC with meticulous follow-up can be recommended as a first line treatment in patients with gastric dysplasia.

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