Transcriptional and Post-transcriptional Mechanisms Modulate Cyclopropane Fatty Acid Synthase Through Small RNAs in

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 2024 Jul 9

PMID 38980083

Authors

Colleen M Bianco

Nancy N Caballero-Rothar

Xiangqian Ma

Kristen R Farley

Carin K Vanderpool

Affiliations

Soon will be listed here.

Abstract

Importance: Bacteria experience many environmental stresses that challenge their membrane integrity. To withstand these challenges, bacteria sense what stress is occurring and mount a response that protects membranes. Previous work documented the important roles of small RNA (sRNA) regulators in membrane stress responses. One sRNA, RydC, helps cells cope with membrane-disrupting stresses by promoting changes in the types of lipids incorporated into membranes. In this study, we identified a regulator, YieP, that controls when RydC is produced and additional sRNA regulators that modulate YieP levels and RydC activity. These findings illuminate a complex regulatory network that helps bacteria sense and respond to membrane stress.

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