» Articles » PMID: 38978623

The MA-ncRNAs Axis in Diabetes Complications: Novel Mechanism and Therapeutic Potential

Overview
Specialty Endocrinology
Date 2024 Jul 9
PMID 38978623
Authors
Affiliations
Soon will be listed here.
Abstract

Diabetes, a multifaceted metabolic disorder, poses a significant global health burden with its increasing prevalence and associated complications, such as diabetic nephropathy, diabetic retinopathy, diabetic cardiomyopathy, and diabetic angiopathy. Recent studies have highlighted the intricate interplay between N-methyladenosine (mA) and non-coding RNAs (ncRNAs) in key pathways implicated in these diabetes complications, like cell apoptosis, oxidative stress, and inflammation. Thus, understanding the mechanistic insights into how mA dysregulation impacts the expression and function of ncRNAs opens new avenues for therapeutic interventions targeting the mA-ncRNAs axis in diabetes complications. This review explores the regulatory roles of mA modifications and ncRNAs, and stresses the role of the mA-ncRNA axis in diabetes complications, providing a therapeutic potential for these diseases.

References
1.
Dai F, Wu Y, Lu Y, An C, Zheng X, Dai L . Crosstalk between RNA mA Modification and Non-coding RNA Contributes to Cancer Growth and Progression. Mol Ther Nucleic Acids. 2020; 22:62-71. PMC: 7486578. DOI: 10.1016/j.omtn.2020.08.004. View

2.
Cole J, Florez J . Genetics of diabetes mellitus and diabetes complications. Nat Rev Nephrol. 2020; 16(7):377-390. PMC: 9639302. DOI: 10.1038/s41581-020-0278-5. View

3.
Shan L, Guo M, Dai Y, Wei L, Zhang W, Gao J . Comprehensive analysis of m6A modification lncRNAs in high glucose and TNF-α induced human umbilical vein endothelial cells. Medicine (Baltimore). 2023; 102(10):e33133. PMC: 9997758. DOI: 10.1097/MD.0000000000033133. View

4.
Feng X, Yang X, Zhong Y, Cheng X . The role of ncRNAs-mediated pyroptosis in diabetes and its vascular complications. Cell Biochem Funct. 2024; 42(2):e3968. DOI: 10.1002/cbf.3968. View

5.
Yue Y, Liu J, Cui X, Cao J, Luo G, Zhang Z . VIRMA mediates preferential mA mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018; 4:10. PMC: 5826926. DOI: 10.1038/s41421-018-0019-0. View