Delayed Rejection of Cardiac Xenografts in C6-deficient Rabbits

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 1979 Oct 1

PMID 389781

Citations 6

Authors

C C ORegan

P Robitaille

C Chartrand

Affiliations

Soon will be listed here.

Abstract

Puppy hearts were engrafted to C6-deficient rabbits, and also to complement-sufficient animals in order to determine the influence of the sixth component of complement on xenograft rejection. Delayed rejection was observed in the puppy hearts engrafted to the C6-deficient animals indicating that complement sufficiency of C6 is required for hyperacute xenograft rejection.

Citing Articles

Recent advances in the immunology of xenotransplantation.

Takahashi T, Saadi S, Platt J Immunol Res. 1997; 16(3):273-97.

PMID: 9379077 DOI: 10.1007/BF02786395.

Role of the terminal complement pathway in experimental membranous nephropathy in the rabbit.

Groggel G, Adler S, Rennke H, Couser W, Salant D J Clin Invest. 1983; 72(6):1948-57.

PMID: 6227634 PMC: 437035. DOI: 10.1172/JCI111159.

Complement-induced glomerular epithelial cell injury. Role of the membrane attack complex in rat membranous nephropathy.

Cybulsky A, Rennke H, Feintzeig I, Salant D J Clin Invest. 1986; 77(4):1096-107.

PMID: 3514672 PMC: 424443. DOI: 10.1172/JCI112408.

Reaction of complement with endothelial cells in a model of xenotransplantation.

Dalmasso A, Platt J, Bach F Clin Exp Immunol. 1991; 86 Suppl 1:31-5.

PMID: 1718641 PMC: 1554041.

Mechanism of complement activation in the hyperacute rejection of porcine organs transplanted into primate recipients.

Dalmasso A, Vercellotti G, Fischel R, Bolman R, Bach F, Platt J Am J Pathol. 1992; 140(5):1157-66.

PMID: 1580328 PMC: 1886521.

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