Age and Sex Differences in the Effects of Short- and Long-term Exposure to Air Pollution on Endothelial Dysfunction

Overview

Journal Environ Health

Publisher Biomed Central

Specialty Environmental Health

Date 2024 Jul 8

PMID 38978038

Authors

Haoyu Zhang

Jing Yang

Yinghua Zhang

Keling Xiao

Yang Wang

Jin Si

Yan Li

Lijie Sun

Jinghao Sun

Ming Yi

Xi Chu

Jing Li

Affiliations

Soon will be listed here.

Abstract

Background: The effects of air pollution on endothelial function remain unclear across populations. We aimed to use brachial artery flow-mediated dilatation (FMD) to identify demographic differences in the effects of air pollution exposure on endothelial dysfunction.

Methods: We measured FMD in 850 participants from October 2016 to January 2020. Location-specific concentrations of fine particulate matter < 2.5 μm aerodynamic diameter (PM), inhalable particulate matter < 10 μm aerodynamic diameter (PM), sulfur dioxide (SO), nitrogen dioxide (NO), carbon monoxide (CO), and ozone (O) measured by fixed ambient air monitoring stations were collected for short- and long-term exposure assessment. Multiple linear regression models and restricted cubic splines were used to assess the associations before and after stratification by age and sex.

Results: This study eventually included 828 participants [551 (66.5%) younger than 65 years and 553 (66.8%) men]. Each 10 µg/m increase in 7-day exposure to PM and PM was significantly linearly associated with a 0.07% (β = -0.07, 95% CI: -0.13 to -0.004) and 0.05% (β = -0.05, 95% CI: -0.10 to -0.004) decrease in FMD in the fully adjusted model. After full adjustment, long-term exposure to all air pollutants was significantly associated with impaired FMD. Each 10 µg/m increase in long-term exposure to PM and PM was significantly associated with a -0.18% (95% CI: -0.34 to -0.03) and - 0.23% (95% CI: -0.40 to -0.06) change in FMD, respectively. After stratification, the associations of lower FMD with long-term exposure to PM, PM, SO, NO, and CO significantly persisted in men and participants younger than 65 years instead of women or older participants. For short-term exposure, we observed differences consistent with long-term exposure and a stronger effect of 7-day exposure to SO in men due to a significant interaction effect.

Conclusion: Short- and long-term exposure to different air pollutants are strongly associated with decreased endothelial function, and susceptibility to air pollution varies significantly with age and sex.

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