Covid-19 Vaccine Hesitancy and Its Predictors Among Diabetic Patients on Follow-up at Public Hospitals in Nekemte Town, Western Ethiopia

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2024 Jul 8

PMID 38976683

Authors

Aberash Olani Kuta

Nagasa Dida

Affiliations

Soon will be listed here.

Abstract

Background: Understanding and addressing the concerns of vaccine-hesitant individuals, including those with chronic diseases, is key to increasing vaccine acceptance and uptake. However, in Ethiopia, there is limited evidence on the COVID-19 vaccine hesitancy and predictor variables among diabetic patients. Hence, the study aimed to assess Covid-19 Vaccine Hesitancy and Predictor variables among Diabetic Patients on Follow-Up at Public Hospitals in Nekemte Town, Western Ethiopia.

Method: Facility based cross sectional study was conducted among 422 diabetic patients attending public hospitals at Nekemte Town, Western Ethiopia between January, to February, 2023. Study participants were recruited by systematic random sampling. The data were collected interviewee administered pre-tested structured survey questioner. The collected data were entered and cleaned using Epi-Data software 4.6 version. The cleaned data were analyzed using SPSS. 25.0 Statical software. Descriptive statistics like frequency, mean and percentage, and binary logistic regression was applied to identify independent predictors of Covid-19 vaccine hesitancy and association between variables were declared at p-value of 0.05.

Result: The overall magnitude of COVID-19 vaccine hesitancy was 15.2% (95% CI: 11.6-18.7). The top three listed reasons for the COVID-19 vaccine hesitancy were: negative information about the vaccine (32.90%), lack of enough information (21.80%), and vaccine safety concern (19.40%). The hesitancy of the COVID-19 vaccination uptake among diabetes patients was independently influenced by age between 40-49 (Adjusted Odd Ratio [AOR] = 4.52(1.04-19.66)), having vaccine awareness (AOR = 0.029(0.001-0.86)), having a great deal of trust on vaccine development (AOR = 0.028(0.002-0.52)), and a fear amount trust (AOR = 0.05(0.003-0.79)) on the vaccine preparation, vaccinated for COVID-19 (AOR = 0.13(0.04-0.51)), perceived exposure to COVID-19 infection after having the vaccine as strongly agree/agree (AOR = 0.03(0.01-0.17))and neither agree nor disagree (AOR = 0.07(0.02-0.30)).

Conclusion: COVID-19 vaccine hesitancy among diabetic patients was relatively low. The identified independent predictors were age, vaccine awareness, COVID-19 vaccination history, awareness on vaccine preparation and exposure status to COVID-19 infection. The relevant agency should focus on efforts to translating these high levels of vaccine acceptance into actual uptake, through targeting identifying predictor variables and vaccine availability for a high-risk diabetes patient.

References

Salali G, Uysal M . COVID-19 vaccine hesitancy is associated with beliefs on the origin of the novel coronavirus in the UK and Turkey. Psychol Med. 2020; :1-3. PMC: 7609204. DOI: 10.1017/S0033291720004067. View

Wang Y, Duan L, Li M, Wang J, Yang J, Song C . COVID-19 Vaccine Hesitancy and Associated Factors among Diabetes Patients: A Cross-Sectional Survey in Changzhi, Shanxi, China. Vaccines (Basel). 2022; 10(1). PMC: 8778010. DOI: 10.3390/vaccines10010129. View

Sirikalyanpaiboon M, Ousirimaneechai K, Phannajit J, Pitisuttithum P, Jantarabenjakul W, Chaiteerakij R . COVID-19 vaccine acceptance, hesitancy, and determinants among physicians in a university-based teaching hospital in Thailand. BMC Infect Dis. 2021; 21(1):1174. PMC: 8607407. DOI: 10.1186/s12879-021-06863-5. View

Sallam M . COVID-19 Vaccine Hesitancy Worldwide: A Concise Systematic Review of Vaccine Acceptance Rates. Vaccines (Basel). 2021; 9(2). PMC: 7920465. DOI: 10.3390/vaccines9020160. View

Larson H, Jarrett C, Eckersberger E, Smith D, Paterson P . Understanding vaccine hesitancy around vaccines and vaccination from a global perspective: a systematic review of published literature, 2007-2012. Vaccine. 2014; 32(19):2150-9. DOI: 10.1016/j.vaccine.2014.01.081. View

Dereje N, Tesfaye A, Tamene B, Alemeshet D, Abe H, Tesfa N . COVID-19 vaccine hesitancy in Addis Ababa, Ethiopia: a mixed-method study. BMJ Open. 2022; 12(5):e052432. PMC: 9152622. DOI: 10.1136/bmjopen-2021-052432. View

Grossman-Giron A, Tzur Bitan D, Shemesh S, Mayer Y, Shiffman N, Bloch Y . COVID-19 vaccine hesitancy scale and its association with actual COVID-19 vaccine uptake in Israel. Vaccine. 2023; 41(9):1567-1572. PMC: 9868364. DOI: 10.1016/j.vaccine.2023.01.044. View

Alagoz O, Sethi A, Patterson B, Churpek M, Alhanaee G, Scaria E . The impact of vaccination to control COVID-19 burden in the United States: A simulation modeling approach. PLoS One. 2021; 16(7):e0254456. PMC: 8279349. DOI: 10.1371/journal.pone.0254456. View

Sahile A, Gizaw G, Mgutshini T, Gebremariam Z, Bekele G . COVID-19 Vaccine Acceptance Level in Ethiopia: A Systematic Review and Meta-Analysis. Can J Infect Dis Med Microbiol. 2022; 2022:2313367. PMC: 9436617. DOI: 10.1155/2022/2313367. View

10.

Dolu I, Turhan Z, Yalniz Dilcen H . COVID-19 Vaccine Acceptance is associated with Vaccine Hesitancy, Perceived Risk and Previous Vaccination Experiences. Disaster Med Public Health Prep. 2021; 17:e97. PMC: 8814475. DOI: 10.1017/dmp.2021.370. View

11.

Machingaidze S, Wiysonge C . Understanding COVID-19 vaccine hesitancy. Nat Med. 2021; 27(8):1338-1339. DOI: 10.1038/s41591-021-01459-7. View

12.

Abdool Karim S, de Oliveira T . New SARS-CoV-2 Variants - Clinical, Public Health, and Vaccine Implications. N Engl J Med. 2021; 384(19):1866-1868. PMC: 8008749. DOI: 10.1056/NEJMc2100362. View

13.

Ekpor E, Akyirem S . Global acceptance of COVID-19 vaccine among persons with diabetes: A systematic review and meta-analysis. Diabetes Res Clin Pract. 2023; 201:110731. PMC: 10207860. DOI: 10.1016/j.diabres.2023.110731. View

14.

Ma L, Liu H, Tao Z, Jiang N, Wang S, Jiang X . Knowledge, Beliefs/Attitudes, and Practices of Rural Residents in the Prevention and Control of COVID-19: An Online Questionnaire Survey. Am J Trop Med Hyg. 2020; 103(6):2357-2367. PMC: 7695081. DOI: 10.4269/ajtmh.20-0314. View

15.

Bianchi F, Stefanizzi P, Martinelli A, Brescia N, Tafuri S . COVID-19 vaccination hesitancy in people affected by diabetes and strategies to increase vaccine compliance: A systematic narrative review and meta-analysis. Vaccine. 2023; 41(7):1303-1309. PMC: 9860503. DOI: 10.1016/j.vaccine.2023.01.036. View

16.

Mohammed R, Nguse T, Habte B, Fentie A, Gebretekle G . COVID-19 vaccine hesitancy among Ethiopian healthcare workers. PLoS One. 2021; 16(12):e0261125. PMC: 8682893. DOI: 10.1371/journal.pone.0261125. View

17.

Tolossa T, Wakuma B, Turi E, Mulisa D, Ayala D, Fetensa G . Attitude of health professionals towards COVID-19 vaccination and associated factors among health professionals, Western Ethiopia: A cross-sectional survey. PLoS One. 2022; 17(3):e0265061. PMC: 8906598. DOI: 10.1371/journal.pone.0265061. View

18.

Osuagwu U, Langsi R, Ovenseri-Ogbomo G, Mashige K, Kwasi Abu E, Envuladu E . Analysis of Perception, Reasons, and Motivations for COVID-19 Vaccination in People with Diabetes across Sub-Saharan Africa: A Mixed-Method Approach. Int J Environ Res Public Health. 2022; 19(13). PMC: 9266073. DOI: 10.3390/ijerph19137875. View

19.

Graffigna G, Palamenghi L, Boccia S, Barello S . Relationship between Citizens' Health Engagement and Intention to Take the COVID-19 Vaccine in Italy: A Mediation Analysis. Vaccines (Basel). 2020; 8(4). PMC: 7711984. DOI: 10.3390/vaccines8040576. View

20.

Mesele H, Shiferaw M, Tunta A, Seid A, Kassahun W . Willingness to Receive COVID-19 Vaccination Among Adult Diabetes Patients in Woldia Comprehensive Specialized Hospital, North Ethiopia; A Cross-Sectional Study. Patient Prefer Adherence. 2022; 16:2451-2459. PMC: 9447444. DOI: 10.2147/PPA.S379531. View