Biofilms: Immune Responses, Role in TB Pathology, and Potential Treatment

Overview

Journal Immunotargets Ther

Publisher Dove Medical Press

Specialty Allergy & Immunology

Date 2024 Jul 8

PMID 38974843

Authors

Muluneh Assefa

Getu Girmay

Affiliations

Soon will be listed here.

Abstract

Tuberculosis (TB) is a major public health problem worldwide, and the burden of drug-resistant TB is rapidly increasing. Although there are literatures about the biofilms, their impact on immune responses has not yet been summarized. This review article provides recent knowledge on () biofilm-immunity interactions, their importance in pulmonary TB pathology, and immune-based therapy targeting biofilms. Pellicle/biofilm formation in contributes to drug resistance, persistence, chronicity, surface attachment, transfer of resistance genes, and modulation of the immune response, including reduced complement activation, changes in the expression of antigenic proteins, enhanced activation of T-lymphocytes, elevated local IFNγ+ T cells, and strong antibody production. The combination of anti-TB drugs and anti-biofilm agents has recently become an effective strategy to improve TB treatment. Additionally, immune-targeted therapy and biofilm-based vaccines are crucial for TB prevention.

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