A Patient with Axial Spondylarthritis Who Experienced Pancytopenia While Receiving Anti-TNF Therapy
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Abstract
Aplastic anemia is a rare and heterogeneous disease that causes pancytopenia and aplasia of the bone marrow. It is characterized by a failure of hematopoiesis. It is believed that approximately 65% of cases of acquired aplastic anemia are idiopathic. In a subset of cases, a drug or infection is the cause of bone marrow failure. This case report presents a 38-year-old patient with axial spondylarthritis who developed pancytopenia and was diagnosed with aplastic anemia during anti-TNF-α treatment.
References
1.
Wronski J, Fiedor P
. The Safety Profile of Tumor Necrosis Factor Inhibitors in Ankylosing Spondylitis: Are TNF Inhibitors Safer Than We Thought?. J Clin Pharmacol. 2018; 59(4):445-462.
DOI: 10.1002/jcph.1348.
View
2.
Kozak N, Friedman J, Schattner A
. Etanercept-associated transient bone marrow aplasia: a review of the literature and pathogenetic mechanisms. Drugs R D. 2014; 14(2):155-8.
PMC: 4070464.
DOI: 10.1007/s40268-014-0050-z.
View
3.
Li J, Zhang Z, Wu X, Zhou J, Meng D, Zhu P
. Risk of Adverse Events After Anti-TNF Treatment for Inflammatory Rheumatological Disease. A Meta-Analysis. Front Pharmacol. 2021; 12:746396.
PMC: 8591221.
DOI: 10.3389/fphar.2021.746396.
View
4.
Bessissow T, Renard M, Hoffman I, Vermeire S, Rutgeerts P, Van Assche G
. Review article: non-malignant haematological complications of anti-tumour necrosis factor alpha therapy. Aliment Pharmacol Ther. 2012; 36(4):312-23.
DOI: 10.1111/j.1365-2036.2012.05189.x.
View
5.
Hastings R, Ding T, Butt S, Gadsby K, Zhang W, Moots R
. Neutropenia in patients receiving anti-tumor necrosis factor therapy. Arthritis Care Res (Hoboken). 2010; 62(6):764-9.
DOI: 10.1002/acr.20037.
View