Phase Separation of RNF214 Promotes the Progression of Hepatocellular Carcinoma

Overview

Journal Cell Death Dis

Specialties Cell Biology
General Medicine

Date 2024 Jul 5

PMID 38969650

Authors

Zheng-Jie He

Ke He

Song-Wang Cai

Rui Zhang

Zhong-Bao Shao

Sheng-Te Wang

Xiao-Peng Li

Yan-Chi Li

Wei-Jing Liu

You-Qing Zhu

Shi-Jie Zeng

Yu-Bin Su

Zhi Shi

Affiliations

Soon will be listed here.

Abstract

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors, and the expression and function of an uncharacterized protein RNF214 in HCC are still unknown. Phase separation has recently been observed to participate in the progression of HCC. In this study, we investigated the expression, function, and phase separation of RNF214 in HCC. We found that RNF214 was highly expressed in HCC and associated with poor prognosis. RNF214 functioned as an oncogene to promote the proliferation, migration, and metastasis of HCC. Mechanically, RNF214 underwent phase separation, and the coiled-coil (CC) domain of RNF214 mediated its phase separation. Furthermore, the CC domain was necessary for the oncogenic function of RNF214 in HCC. Taken together, our data favored that phase separation of RNF214 promoted the progression of HCC. RNF214 may be a potential biomarker and therapeutic target for HCC.

Citing Articles

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Zhang X, Yang Z, Fu C, Yao R, Li H, Peng F Cell Commun Signal. 2024; 22(1):430.

PMID: 39227829 PMC: 11373118. DOI: 10.1186/s12964-024-01787-4.

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