The Clinical Significance of Inflammatory Mediators in Predicting Obesity and Progression-free Survival in Patients with Adult-onset Craniopharyngioma

Overview

Journal BMC Cancer

Publisher Biomed Central

Specialty Oncology

Date 2024 Jul 4

PMID 38965454

Authors

Youchao Xiao

Wentao Wu

Fangzheng Liu

Yanfei Jia

Lu Jin

Ning Qiao

Kefan Cai

Siming Ru

Lei Cao

Songbai Gui

Affiliations

Soon will be listed here.

Abstract

Background: Craniopharyngioma (CP) is a rare malformational tumor characterized by high rates of recurrence and morbid obesity. However, the role of inflammatory mediators in obesity and the prognosis of patients with CP remains unknown. Therefore, the present study aimed to analyze associations of inflammatory mediators with weight-related outcomes and the prognosis of patients with CP.

Methods: A total of 130 consecutive patients with CP were included in this study. The expression levels of seven inflammatory mediators and the plasma leptin concentration were investigated. Clinical parameters, weight changes, new-onset obesity, and progression-free survival (PFS) were recorded. The relationships between inflammatory mediators, clinicopathologic parameters, weight-related outcomes, and PFS were explored.

Results: Compared with those in normal pituitary tissue, the expressions of inflammatory mediators in tumor tissue were higher. Higher expression levels of CXCL1 and CXCL8 were identified as independent risk factors for significant weight gain, and CXCL1 and TNF were identified as independent risk factors for new-onset postoperative obesity. Poor PFS was associated with higher expression levels of CXCL1, CXCL8, IL1A, IL6, and TNF.

Conclusion: The present study revealed that inflammatory mediators are associated with morbid obesity in patients with CP. Inflammatory mediators may be the critical bridge between elevated leptin and weight-related outcomes. Additionally, PFS was associated with the expression of inflammatory mediators. Further research is needed to elucidate the underlying mechanisms of inflammatory mediators and their potential as targets for novel therapies for CP.

Citing Articles

Inflammatory mediator contributes to leptin resistance and obesity in craniopharyngioma.

Xiao Y, Wu W, Liu F, Jin L, Jia Y, Qiao N FASEB J. 2024; 38(23):e70242.

PMID: 39655658 PMC: 11629452. DOI: 10.1096/fj.202402216RR.

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