The Efficacy of Platelet and Leukocyte Rich Fibrin (L-PRF) in the Healing Process and Bone Repair in Oral and Maxillofacial Surgeries: a Systematic Review

Overview

Journal Clin Oral Investig

Specialty Dentistry

Date 2024 Jul 4

PMID 38965076

Authors

Eduardo Dias Ribeiro

Ilan Hudson Gomes de Santana

Mayara Rebeca Martins Viana

Evaldo Sales Honfi Junior

Julliana Cariry Palhano Dias

Osny Ferreira-Junior

Eduardo SantAna

Affiliations

Soon will be listed here.

Abstract

Introduction: The search to optimize the healing and bone repair processes in oral and maxillofacial surgeries reflects the constant evolution in clinical practice, driven by the demand for increasingly satisfactory results and the need to minimize postoperative complications.

Objective: To evaluate the efficacy of Platelet and Leukocyte Rich Fibrin (L-PRF) in the healing and bone repair process in oral and maxillofacial surgeries.

Materials And Methods: The systematic review protocol for this study included the definition of the research question, the domain of the study, the databases searched, the search strategy, the inclusion and exclusion criteria, the types of studies to be included, the measures of effect, the methods for screening, data extraction and analysis, and the approach to data synthesis. Systematic literature searches were carried out on Cochrane databases, Web of Science, PubMed, ScienceDirect, Embase and Google Scholar.

Results: The strategic search in the databases identified 1,159 studies. After removing the duplicates with the Rayyan© software, 946 articles remained. Of these, 30 met the inclusion criteria. After careful evaluation based on the inclusion and exclusion criteria, 8 studies were considered highly relevant and included in the systematic review.

Conclusion: Platelet and Leukocyte Rich Fibrin (L-PRF) has a positive effect on the healing process and bone repair in oral and maxillofacial surgeries.

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