Metformin Prevents the Onset and Progression of Intervertebral Disc Degeneration: New Insights and Potential Mechanisms (Review)

Overview

Journal Int J Mol Med

Specialty Genetics

Date 2024 Jul 4

PMID 38963023

Authors

Wenzhi Yang

Yipin Yang

Yong Wang

Zongshi Gao

Jingtang Zhang

Weimin Gao

Yanjun Chen

You Lu

Haoyu Wang

Lingyan Zhou

Yifan Wang

Jie Li

Hui Tao

Affiliations

Soon will be listed here.

Abstract

Metformin has been the go‑to medical treatment for addressing type 2 diabetes mellitus (T2DM) as a frontline oral antidiabetic. Obesity, cancer and bone deterioration are linked to T2DM, which is considered a metabolic illness. Numerous diseases associated with T2DM, such as tumours, cardiovascular disease and bone deterioration, may be treated with metformin. Intervertebral disc degeneration (IVDD) is distinguished by degeneration of the spinal disc, accompanied by the gradual depletion of proteoglycans and water in the nucleus pulposus (NP) of the IVD, resulting in lower back pain. The therapeutic effect of metformin on IVDD has also attracted much attention. By stimulating AMP‑activated kinase, metformin could enhance autophagy and suppress cell senescence, apoptosis and inflammation, thus effectively delaying IVDD. The present review aimed to systematically explain the development of IVDD and mechanism of metformin in the treatment and prevention of IVDD to provide a reference for the clinical application of metformin as adjuvant therapy in the treatment of IVDD.

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