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Non-human Primate Studies for Cardiomyocyte Transplantation-ready for Translation?

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Journal Front Pharmacol
Date 2024 Jul 4
PMID 38962314
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Abstract

Non-human primates (NHP) are valuable models for late translational pre-clinical studies, often seen as a last step before clinical application. The unique similarity between NHPs and humans is often the subject of ethical concerns. However, it is precisely this analogy in anatomy, physiology, and the immune system that narrows the translational gap to other animal models in the cardiovascular field. Cell and gene therapy approaches are two dominant strategies investigated in the research field of cardiac regeneration. Focusing on the cell therapy approach, several xeno- and allogeneic cell transplantation studies with a translational motivation have been realized in macaque species. This is based on the pressing need for novel therapeutic options for heart failure patients. Stem cell-based remuscularization of the injured heart can be achieved via direct injection of cardiomyocytes (CMs) or patch application. Both CM delivery approaches are in the late preclinical stage, and the first clinical trials have started. However, are we already ready for the clinical area? The present review concentrates on CM transplantation studies conducted in NHPs, discusses the main sources and discoveries, and provides a perspective about human translation.

References
1.
Weinberger F, Eschenhagen T . Cardiac Regeneration: New Hope for an Old Dream. Annu Rev Physiol. 2020; 83:59-81. DOI: 10.1146/annurev-physiol-031120-103629. View

2.
Nelson T, Martinez-Fernandez A, Yamada S, Perez-Terzic C, Ikeda Y, Terzic A . Repair of acute myocardial infarction by human stemness factors induced pluripotent stem cells. Circulation. 2009; 120(5):408-16. PMC: 2768575. DOI: 10.1161/CIRCULATIONAHA.109.865154. View

3.
Herrington W, Lacey B, Sherliker P, Armitage J, Lewington S . Epidemiology of Atherosclerosis and the Potential to Reduce the Global Burden of Atherothrombotic Disease. Circ Res. 2016; 118(4):535-46. DOI: 10.1161/CIRCRESAHA.115.307611. View

4.
von Bibra C, Shibamiya A, Geertz B, Querdel E, Kohne M, Studemann T . Human engineered heart tissue transplantation in a guinea pig chronic injury model. J Mol Cell Cardiol. 2022; 166:1-10. DOI: 10.1016/j.yjmcc.2022.01.007. View

5.
Laflamme M, Chen K, Naumova A, Muskheli V, Fugate J, Dupras S . Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts. Nat Biotechnol. 2007; 25(9):1015-24. DOI: 10.1038/nbt1327. View