Ferroptosis Resistance in Cancer Cells: Nanoparticles for Combination Therapy As a Solution

Overview

Journal Front Pharmacol

Date 2024 Jul 4

PMID 38962305

Authors

Kodzo Prosper Adzavon

Weijian Zhao

Xuesong He

Wang Sheng

Affiliations

Soon will be listed here.

Abstract

Ferroptosis is a form of regulated cell death (RCD) characterized by iron-dependent lipid peroxidation. Ferroptosis is currently proposed as one of the most promising means of combating tumor resistance. Nevertheless, the problem of ferroptosis resistance in certain cancer cells has been identified. This review first, investigates the mechanisms of ferroptosis induction in cancer cells. Next, the problem of cancer cell resistance to ferroptosis, as well as the underlying mechanisms is discussed. Recently discovered ferroptosis-suppressing biomarkers have been described. The various types of nanoparticles that can induce ferroptosis are also discussed. Given the ability of nanoparticles to combine multiple agents, this review proposes nanoparticle-based ferroptosis cell death as a viable method of circumventing this resistance. This review suggests combining ferroptosis with other forms of cell death, such as apoptosis, cuproptosis and autophagy. It also suggests combining ferroptosis with immunotherapy.

Citing Articles

Review to Elucidate the Correlation between Cuproptosis-Related Genes and Immune Infiltration for Enhancing the Detection and Treatment of Cervical Cancer.

Pandey P, Ramniwas S, Pandey S, Lakhanpal S, Padmapriya G, Mishra S Int J Mol Sci. 2024; 25(19).

PMID: 39408933 PMC: 11477161. DOI: 10.3390/ijms251910604.

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