Synthesis of Current Pediatric Urinary Microbiome Research

Overview

Journal Front Pediatr

Specialty Pediatrics

Date 2024 Jul 3

PMID 38957777

Authors

Layla M Jeries

Tatyana A Sysoeva

Lisa Karstens

Maryellen S Kelly

Affiliations

Soon will be listed here.

Abstract

The human urinary bladder hosts a complex microbial community of low biomass referred to as the urobiome. While the composition of the urobiome has been investigated in adults for over a decade now, only a few studies have considered the presence and composition of the urobiome in children. It is critical to explore how the urobiome develops throughout the life span and how it changes in the presence of various health conditions. Therefore, we set to review the available data on pediatric urobiome composition and its development with age and disease. In addition, we focused on identifying and reporting specific gaps in our knowledge of the pediatric urobiome that we hope will be addressed by future studies in this swiftly developing field with fast-improving methods and consensus.

References

Storm D, Copp H, Halverson T, Du J, Juhr D, Wolfe A . A Child's urine is not sterile: A pilot study evaluating the Pediatric Urinary Microbiome. J Pediatr Urol. 2022; 18(3):383-392. DOI: 10.1016/j.jpurol.2022.02.025. View

Bajic P, Van Kuiken M, Burge B, Kirshenbaum E, Joyce C, Wolfe A . Male Bladder Microbiome Relates to Lower Urinary Tract Symptoms. Eur Urol Focus. 2018; 6(2):376-382. DOI: 10.1016/j.euf.2018.08.001. View

Shipman B, Nguyen A, Sharon B, Zimmern P, De Nisco N . Complete Genome Sequences of Three Lactobacillus gasseri Urine Isolates Obtained from Postmenopausal Women. Microbiol Resour Announc. 2022; 11(9):e0048122. PMC: 9476926. DOI: 10.1128/mra.00481-22. View

Wang F, Wang Z, Tang J . The interactions of Candida albicans with gut bacteria: a new strategy to prevent and treat invasive intestinal candidiasis. Gut Pathog. 2023; 15(1):30. PMC: 10294497. DOI: 10.1186/s13099-023-00559-8. View

Gharanfoli A, Mahmoudi E, Torabizadeh R, Katiraee F, Faraji S . Isolation, characterization, and molecular identification of species from urinary tract infections. Curr Med Mycol. 2019; 5(2):33-36. PMC: 6626715. DOI: 10.18502/cmm.5.2.1159. View

Vendrell J, Henry S, Cabello-Aguilar S, Heckendorn E, Godreuil S, Solassol J . Determination of the Optimal Bacterial DNA Extraction Method to Explore the Urinary Microbiota. Int J Mol Sci. 2022; 23(3). PMC: 8835916. DOI: 10.3390/ijms23031336. View

Siddiqui N, Ma L, Brubaker L, Mao J, Hoffman C, Dahl E . Updating Urinary Microbiome Analyses to Enhance Biologic Interpretation. Front Cell Infect Microbiol. 2022; 12:789439. PMC: 9309214. DOI: 10.3389/fcimb.2022.789439. View

Johnson J, Modliszewski J, Siddiqui N, Sysoeva T . Draft Genome Sequence of a Lactobacillus gasseri Strain Isolated from the Catheterized Urine of a Healthy Postmenopausal Woman. Microbiol Resour Announc. 2022; 11(6):e0002122. PMC: 9202440. DOI: 10.1128/mra.00021-22. View

Mueller E, Wolfe A, Brubaker L . Female urinary microbiota. Curr Opin Urol. 2017; 27(3):282-286. PMC: 5521999. DOI: 10.1097/MOU.0000000000000396. View

10.

Garretto A, Thomas-White K, Wolfe A, Putonti C . Detecting viral genomes in the female urinary microbiome. J Gen Virol. 2018; 99(8):1141-1146. PMC: 6171713. DOI: 10.1099/jgv.0.001097. View

11.

Santiago-Rodriguez T, Ly M, Bonilla N, Pride D . The human urine virome in association with urinary tract infections. Front Microbiol. 2015; 6:14. PMC: 4304238. DOI: 10.3389/fmicb.2015.00014. View

12.

Song C, Kim Y, Naskar M, Hayes B, Abraham M, Noh J . Limits Bladder Uropathogenic Infection by Triggering a Host Type I Interferon Response. Proc Natl Acad Sci U S A. 2022; 119(33):e2117904119. PMC: 9388105. DOI: 10.1073/pnas.2117904119. View

13.

Mirzayi C, Renson A, Zohra F, Elsafoury S, Geistlinger L, Kasselman L . Reporting guidelines for human microbiome research: the STORMS checklist. Nat Med. 2021; 27(11):1885-1892. PMC: 9105086. DOI: 10.1038/s41591-021-01552-x. View

14.

Hasman H, Saputra D, Sicheritz-Ponten T, Lund O, Svendsen C, Frimodt-Moller N . Rapid whole-genome sequencing for detection and characterization of microorganisms directly from clinical samples. J Clin Microbiol. 2013; 52(1):139-46. PMC: 3911411. DOI: 10.1128/JCM.02452-13. View

15.

Garcia-Lopez R, Cornejo-Granados F, Lopez-Zavala A, Cota-Huizar A, Sotelo-Mundo R, Gomez-Gil B . OTUs and ASVs Produce Comparable Taxonomic and Diversity from Shrimp Microbiota 16S Profiles Using Tailored Abundance Filters. Genes (Basel). 2021; 12(4). PMC: 8070570. DOI: 10.3390/genes12040564. View

16.

Farrokhi Y, Al-Shibli B, Al-Hameedawi D, Neshati Z, Makhdoumi A . Escherichia coli enhances the virulence factors of Candida albicans, the cause of vulvovaginal candidiasis, in a dual bacterial/fungal biofilm. Res Microbiol. 2021; 172(4-5):103849. DOI: 10.1016/j.resmic.2021.103849. View

17.

Thapaliya J, Khadka P, Thapa S, Gongal C . Enhanced quantitative urine culture technique, a slight modification, in detecting under-diagnosed pediatric urinary tract infection. BMC Res Notes. 2020; 13(1):5. PMC: 6942300. DOI: 10.1186/s13104-019-4875-y. View

18.

Komesu Y, Richter H, Carper B, Dinwiddie D, Lukacz E, Siddiqui N . The urinary microbiome in women with mixed urinary incontinence compared to similarly aged controls. Int Urogynecol J. 2018; 29(12):1785-1795. PMC: 6295358. DOI: 10.1007/s00192-018-3683-6. View

19.

Kelly M, Dahl E, Jeries L, Sysoeva T, Karstens L . Characterization of pediatric urinary microbiome at species-level resolution indicates variation due to sex, age, and urologic history. J Pediatr Urol. 2024; 20(5):884-893. DOI: 10.1016/j.jpurol.2024.05.016. View

20.

Hilt E, Putonti C, Thomas-White K, Lewis A, Visick K, Gilbert N . Aerococcus urinae Isolated from Women with Lower Urinary Tract Symptoms: Aggregation and Genome Analysis. J Bacteriol. 2020; 202(13). PMC: 7283593. DOI: 10.1128/JB.00170-20. View