Mortality and Neurodevelopmental Outcomes at 2 years' Corrected Age of Very Preterm Infants with Necrotising Enterocolitis or Spontaneous Intestinal Perforation: The EPIPAGE-2 Cohort Study

Overview

Journal Eur J Pediatr

Specialty Pediatrics

Date 2024 Jul 2

PMID 38955846

Authors

Victoria Butler

Ludovic Treluyer

Juliana Patkai

Aline Biset

Pierre-Henri Jarreau

Pierre-Yves Ancel

Jean-Christophe Roze

Laetitia Marchand-Martin

Melanie Durox

Alexandre Lapillonne

Jean-Charles Picaud

Delphine Mitanchez

Charlotte Tscherning

Valerie Biran

Gilles Cambonie

Emmanuel Lopez

Jean-Michel Hascoet

Luc Desfrere

Clement Chollat

Elodie Zana-Taieb

Heloise Torchin

Affiliations

Soon will be listed here.

Abstract

Purpose: The primary objective was to evaluate the impact of necrotising enterocolitis (NEC) and spontaneous intestinal perforation (SIP) on mortality and neurodevelopmental outcomes at 2 years' corrected age (CA) in infants born before 32 weeks' gestation (WG).

Methods: We studied neurodevelopment at 2 years' CA of infants with NEC or SIP who were born before 32 WG from the EPIPAGE-2 cohort study. The primary outcome was death or the presence of moderate-to-severe motor or sensory disability defined by moderate-to-severe cerebral palsy or hearing or visual disability. The secondary outcome was developmental delay defined by a score < 2 SDs below the mean for any of the five domains of the Ages and Stages Questionnaire.

Results: At 2 years' CA, 46% of infants with SIP, 34% of infants with NEC, and 14% of control infants died or had a moderate-to-severe sensorimotor disability (p < 0.01). This difference was mainly due to an increase in in-hospital mortality in the infants with SIP or NEC. Developmental delay at 2 years' CA was more frequent for infants with SIP than controls (70.8% vs 44.0%, p = 0.02) but was similar for infants with NEC and controls (49.3% vs 44.0%, p = 0.5). On multivariate analysis, the likelihood of developmental delay was associated with SIP (adjusted odds ratio = 3.0, 95% CI 1.0-9.1) but not NEC as compared with controls.

Conclusion: NEC and SIP significantly increased the risk of death or sensorimotor disability at 2 years' CA. SIP was also associated with risk of developmental delay at 2 years' CA.

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