Single-cell Transcriptomic Reveals a Cell Atlas and Diversity of Chicken Amygdala Responded to Social Hierarchy

Overview

Journal iScience

Publisher Cell Press

Date 2024 Jul 2

PMID 38952686

Authors

Siyu Chen

Limin Xing

Zhijiang Xie

Mengqiao Zhao

Hui Yu

Jiankang Gan

Haiquan Zhao

Zheng Ma

Hua Li

Affiliations

Soon will be listed here.

Abstract

Amygdala serves as a highly cellular, heterogeneous brain region containing excitatory and inhibitory neurons and is involved in the dopamine and serotoninergic neuron systems. An increasing number of studies have revealed the underpinned mechanism mediating social hierarchy in mammal and vertebrate, however, there are rare studies conducted on how amygdala on social hierarchy in poultry. In this study, we conducted food competition tests and determined the social hierarchy of the rooster. We performed cross-species analysis with mammalian amygdala, and found that cell types of human and rhesus monkeys were more closely related and that of chickens were more distant. We identified 26 clusters and divided them into 10 main clusters, of which GABAergic and glutamatergic neurons were associated with social behaviors. In conclusion, our results provide to serve the developmental studies of the amygdala neuron system and new insights into the underpinned mechanism of social hierarchy in roosters.

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