» Articles » PMID: 38949997

Beyond Fission and Fusion-Diving into the Mysteries of Mitochondrial Shape

Overview
Journal PLoS Biol
Specialty Biology
Date 2024 Jul 1
PMID 38949997
Authors
Affiliations
Soon will be listed here.
Abstract

Mitochondrial shape and network formation have been primarily associated with the well-established processes of fission and fusion. However, recent research has unveiled an intricate and multifaceted landscape of mitochondrial morphology that extends far beyond the conventional fission-fusion paradigm. These less-explored dimensions harbor numerous unresolved mysteries. This review navigates through diverse processes influencing mitochondrial shape and network formation, highlighting the intriguing complexities and gaps in our understanding of mitochondrial architecture. The exploration encompasses various scales, from biophysical principles governing membrane dynamics to molecular machineries shaping mitochondria, presenting a roadmap for future research in this evolving field.

References
1.
Chan D . Fusion and fission: interlinked processes critical for mitochondrial health. Annu Rev Genet. 2012; 46:265-87. DOI: 10.1146/annurev-genet-110410-132529. View

2.
von der Malsburg A, Sapp G, Zuccaro K, von Appen A, Moss 3rd F, Kalia R . Structural mechanism of mitochondrial membrane remodelling by human OPA1. Nature. 2023; 620(7976):1101-1108. PMC: 10875962. DOI: 10.1038/s41586-023-06441-6. View

3.
Li H, Ruan Y, Zhang K, Jian F, Hu C, Miao L . Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization. Cell Death Differ. 2015; 23(3):380-92. PMC: 5072434. DOI: 10.1038/cdd.2015.102. View

4.
Voeltz G, Prinz W, Shibata Y, Rist J, Rapoport T . A class of membrane proteins shaping the tubular endoplasmic reticulum. Cell. 2006; 124(3):573-86. DOI: 10.1016/j.cell.2005.11.047. View

5.
Martins de Brito O, Scorrano L . Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature. 2008; 456(7222):605-10. DOI: 10.1038/nature07534. View