» Articles » PMID: 38948763

An Open-Source Deep Learning-Based GUI Toolbox For Automated Auditory Brainstem Response Analyses (ABRA)

Overview
Journal bioRxiv
Date 2024 Jul 1
PMID 38948763
Authors
Affiliations
Soon will be listed here.
Abstract

In this paper, we introduce a new, open-source software developed in Python for analyzing Auditory Brainstem Response (ABR) waveforms. ABRs are a far-field recording of synchronous neural activity generated by the auditory fibers in the ear in response to sound, and used to study acoustic neural information traveling along the ascending auditory pathway. Common ABR data analysis practices are subject to human interpretation and are labor-intensive, requiring manual annotations and visual estimation of hearing thresholds. The proposed new Auditory Brainstem Response Analyzer (ABRA) software is designed to facilitate the analysis of ABRs by supporting batch data import/export, waveform visualization, and statistical analysis. Techniques implemented in this software include algorithmic peak finding, threshold estimation, latency estimation, time warping for curve alignment, and 3D plotting of ABR waveforms over stimulus frequencies and decibels. The excellent performance on a large dataset of ABR collected from three labs in the field of hearing research that use different experimental recording settings illustrates the efficacy, flexibility, and wide utility of ABRA.

References
1.
Celik N, OBrien F, Brennan S, Rainbow R, Dart C, Zheng Y . Deep-Channel uses deep neural networks to detect single-molecule events from patch-clamp data. Commun Biol. 2020; 3(1):3. PMC: 6946689. DOI: 10.1038/s42003-019-0729-3. View

2.
Bramhall N, McMillan G, Kujawa S, Konrad-Martin D . Use of non-invasive measures to predict cochlear synapse counts. Hear Res. 2018; 370:113-119. PMC: 7161203. DOI: 10.1016/j.heares.2018.10.006. View

3.
Melcher J, Knudson I, Fullerton B, Guinan Jr J, Norris B, Kiang N . Generators of the brainstem auditory evoked potential in cat. I. An experimental approach to their identification. Hear Res. 1996; 93(1-2):1-27. DOI: 10.1016/0378-5955(95)00178-6. View

4.
Bao J, Jegede S, Hawks J, Dade B, Guan Q, Middaugh S . Detecting Cochlear Synaptopathy Through Curvature Quantification of the Auditory Brainstem Response. Front Cell Neurosci. 2022; 16:851500. PMC: 8959412. DOI: 10.3389/fncel.2022.851500. View

5.
Ingham N, Pearson S, Steel K . Using the Auditory Brainstem Response (ABR) to Determine Sensitivity of Hearing in Mutant Mice. Curr Protoc Mouse Biol. 2015; 1(2):279-87. DOI: 10.1002/9780470942390.mo110059. View