» Articles » PMID: 38948534

Accelerated Partial Breast Irradiation: Current Evidence and Future Developments

Overview
Journal Cancer Innov
Date 2024 Jul 1
PMID 38948534
Authors
Affiliations
Soon will be listed here.
Abstract

Whole breast irradiation after breast-conserving surgery for early breast cancer has become one of the standard treatment modes for breast cancer and yields the same effect as radical surgery. Accelerated partial breast irradiation (APBI) as a substitute for whole breast irradiation for patients with early breast cancer is a hot spot in clinical research. APBI is characterised by simple high-dose local irradiation of the tumour bed in a short time, thus improving convenience for patients and saving costs. The implementation methods of APBI mainly include brachytherapy, external beam radiation therapy, and intraoperative radiotherapy. This review provides an overview of the clinical effects and adverse reactions of the main technologies of APBI and discusses the prospects for the future development of APBI.

References
1.
Pasalic D, Strom E, Allen P, Williamson T, Poenisch F, Amos R . Proton Accelerated Partial Breast Irradiation: Clinical Outcomes at a Planned Interim Analysis of a Prospective Phase 2 Trial. Int J Radiat Oncol Biol Phys. 2020; 109(2):441-448. DOI: 10.1016/j.ijrobp.2020.09.009. View

2.
Orecchia R, Veronesi U, Maisonneuve P, Galimberti V, Lazzari R, Veronesi P . Intraoperative irradiation for early breast cancer (ELIOT): long-term recurrence and survival outcomes from a single-centre, randomised, phase 3 equivalence trial. Lancet Oncol. 2021; 22(5):597-608. DOI: 10.1016/S1470-2045(21)00080-2. View

3.
Bosma S, Hoogstraat M, van der Leij F, de Maaker M, Wesseling J, Lips E . Response to Preoperative Radiation Therapy in Relation to Gene Expression Patterns in Breast Cancer Patients. Int J Radiat Oncol Biol Phys. 2019; 106(1):174-181. DOI: 10.1016/j.ijrobp.2019.09.002. View

4.
Kunkler I, Williams L, Jack W, Cameron D, Dixon J . Breast-conserving surgery with or without irradiation in women aged 65 years or older with early breast cancer (PRIME II): a randomised controlled trial. Lancet Oncol. 2015; 16(3):266-73. DOI: 10.1016/S1470-2045(14)71221-5. View

5.
Fisher B, Anderson S, Bryant J, Margolese R, Deutsch M, Fisher E . Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med. 2002; 347(16):1233-41. DOI: 10.1056/NEJMoa022152. View