Microbiome-driven Anticancer Therapy: A Step Forward from Natural Products

Overview

Journal mLife

Date 2024 Jul 1

PMID 38948147

Authors

Yunxuan Guan

Di Wu

Hui Wang

Ning-Ning Liu

Affiliations

Soon will be listed here.

Abstract

Human microbiomes, considered as a new emerging and enabling cancer hallmark, are increasingly recognized as critical effectors in cancer development and progression. Manipulation of microbiome revitalizing anticancer therapy from natural products shows promise toward improving cancer outcomes. Herein, we summarize our current understanding of the human microbiome-driven molecular mechanisms impacting cancer progression and anticancer therapy. We highlight the potential translational and clinical implications of natural products for cancer prevention and treatment by developing targeted therapeutic strategies as adjuvants for chemotherapy and immunotherapy against tumorigenesis. The challenges and opportunities for future investigations using modulation of the microbiome for cancer treatment are further discussed in this review.

References

SCHELINE R . Metabolism of foreign compounds by gastrointestinal microorganisms. Pharmacol Rev. 1973; 25(4):451-523. View

Atiq A, Shal B, Naveed M, Khan A, Ali J, Zeeshan S . Diadzein ameliorates 5-fluorouracil-induced intestinal mucositis by suppressing oxidative stress and inflammatory mediators in rodents. Eur J Pharmacol. 2018; 843:292-306. DOI: 10.1016/j.ejphar.2018.12.014. View

Rubinstein M, Baik J, Lagana S, Han R, Raab W, Sahoo D . promotes colorectal cancer by inducing Wnt/β-catenin modulator Annexin A1. EMBO Rep. 2019; 20(4). PMC: 6446206. DOI: 10.15252/embr.201847638. View

van Vliet M, Harmsen H, de Bont E, Tissing W . The role of intestinal microbiota in the development and severity of chemotherapy-induced mucositis. PLoS Pathog. 2010; 6(5):e1000879. PMC: 2877735. DOI: 10.1371/journal.ppat.1000879. View

Jin H, Wang L, Bernards R . Rational combinations of targeted cancer therapies: background, advances and challenges. Nat Rev Drug Discov. 2022; 22(3):213-234. DOI: 10.1038/s41573-022-00615-z. View

Hollands A, Corriden R, Gysler G, Dahesh S, Olson J, Ali S . Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal Activity. J Biol Chem. 2016; 291(27):13964-13973. PMC: 4933157. DOI: 10.1074/jbc.M115.695866. View

Pollet R, DAgostino E, Walton W, Xu Y, Little M, Biernat K . An Atlas of β-Glucuronidases in the Human Intestinal Microbiome. Structure. 2017; 25(7):967-977.e5. PMC: 5533298. DOI: 10.1016/j.str.2017.05.003. View

Chiang M, Hsiao P, Liu Y, Tang H, Chiou C, Lu M . Two ST11 strains exacerbate colorectal tumorigenesis in a colitis-associated mouse model. Gut Microbes. 2021; 13(1):1980348. PMC: 8496539. DOI: 10.1080/19490976.2021.1980348. View

Qin D, Zheng Q, Zhang P, Lin S, Huang S, Cheng D . Azadirachtin directly or indirectly affects the abundance of intestinal flora of Spodoptera litura and the energy conversion of intestinal contents mediates the energy balance of intestine-brain axis, and along with decreased expression CREB in the.... Pestic Biochem Physiol. 2021; 173:104778. DOI: 10.1016/j.pestbp.2021.104778. View

10.

Baruch E, Youngster I, Ben-Betzalel G, Ortenberg R, Lahat A, Katz L . Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients. Science. 2020; 371(6529):602-609. DOI: 10.1126/science.abb5920. View

11.

Bhatt A, Pellock S, Biernat K, Walton W, Wallace B, Creekmore B . Targeted inhibition of gut bacterial β-glucuronidase activity enhances anticancer drug efficacy. Proc Natl Acad Sci U S A. 2020; 117(13):7374-7381. PMC: 7132129. DOI: 10.1073/pnas.1918095117. View

12.

Rubinstein M, Wang X, Liu W, Hao Y, Cai G, Han Y . Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/β-catenin signaling via its FadA adhesin. Cell Host Microbe. 2013; 14(2):195-206. PMC: 3770529. DOI: 10.1016/j.chom.2013.07.012. View

13.

Riquelme E, Zhang Y, Zhang L, Montiel M, Zoltan M, Dong W . Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes. Cell. 2019; 178(4):795-806.e12. PMC: 7288240. DOI: 10.1016/j.cell.2019.07.008. View

14.

Bessell C, Isser A, Havel J, Lee S, Bell D, Hickey J . Commensal bacteria stimulate antitumor responses via T cell cross-reactivity. JCI Insight. 2020; 5(8). PMC: 7205429. DOI: 10.1172/jci.insight.135597. View

15.

Brennan C, Garrett W . Fusobacterium nucleatum - symbiont, opportunist and oncobacterium. Nat Rev Microbiol. 2018; 17(3):156-166. PMC: 6589823. DOI: 10.1038/s41579-018-0129-6. View

16.

Chu Z, McKinsey T, Liu L, Gentry J, Malim M, Ballard D . Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control. Proc Natl Acad Sci U S A. 1997; 94(19):10057-62. PMC: 23303. DOI: 10.1073/pnas.94.19.10057. View

17.

Ben Lagha A, Dudonne S, Desjardins Y, Grenier D . Wild Blueberry (Vaccinium angustifolium Ait.) Polyphenols Target Fusobacterium nucleatum and the Host Inflammatory Response: Potential Innovative Molecules for Treating Periodontal Diseases. J Agric Food Chem. 2015; 63(31):6999-7008. DOI: 10.1021/acs.jafc.5b01525. View

18.

Luu M, Riester Z, Baldrich A, Reichardt N, Yuille S, Busetti A . Microbial short-chain fatty acids modulate CD8 T cell responses and improve adoptive immunotherapy for cancer. Nat Commun. 2021; 12(1):4077. PMC: 8249424. DOI: 10.1038/s41467-021-24331-1. View

19.

Yang Y, Weng W, Peng J, Hong L, Yang L, Toiyama Y . Fusobacterium nucleatum Increases Proliferation of Colorectal Cancer Cells and Tumor Development in Mice by Activating Toll-Like Receptor 4 Signaling to Nuclear Factor-κB, and Up-regulating Expression of MicroRNA-21. Gastroenterology. 2016; 152(4):851-866.e24. PMC: 5555435. DOI: 10.1053/j.gastro.2016.11.018. View

20.

Chang A, Golob J, Schmidt T, Peltier D, Lao C, Tewari M . Targeting the Gut Microbiome to Mitigate Immunotherapy-Induced Colitis in Cancer. Trends Cancer. 2021; 7(7):583-593. DOI: 10.1016/j.trecan.2021.02.005. View