Aberrant Immunity in the Oral Cavity-a Link with Rheumatoid Arthritis?

Overview

Journal Front Oral Health

Date 2024 Jul 1

PMID 38948089

Authors

Jennifer Malcolm

Shauna Culshaw

Affiliations

Soon will be listed here.

Abstract

There are well established epidemiological links between rheumatoid arthritis and periodontitis. Recent data have started to shed light on the mechanisms that might underlie the relationship between these two complex diseases. Unravelling the roles of distinct pathways involved in these mechanisms has the potential to yield novel preventative and therapeutic strategies for both diseases. Perhaps most intriguingly, this represents an area where understanding the biology in the oral cavity might reveal fundamental advances in understanding immune regulation and the relationships between the host and microbiome. Here we seek to discuss aspects of the adaptive immune response that might link periodontitis and rheumatoid arthritis.

References

Moudgil K, Sercarz E . Dominant determinants in hen eggwhite lysozyme correspond to the cryptic determinants within its self-homologue, mouse lysozyme: implications in shaping of the T cell repertoire and autoimmunity. J Exp Med. 1993; 178(6):2131-8. PMC: 2191305. DOI: 10.1084/jem.178.6.2131. View

Hajishengallis G, Liang S, Payne M, Hashim A, Jotwani R, Eskan M . Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement. Cell Host Microbe. 2011; 10(5):497-506. PMC: 3221781. DOI: 10.1016/j.chom.2011.10.006. View

Klareskog L, Malmstrom V, Lundberg K, Padyukov L, Alfredsson L . Smoking, citrullination and genetic variability in the immunopathogenesis of rheumatoid arthritis. Semin Immunol. 2011; 23(2):92-8. DOI: 10.1016/j.smim.2011.01.014. View

Curran A, Girgis A, Jang Y, Crawford J, Thomas M, Kawalerski R . Citrullination modulates antigen processing and presentation by revealing cryptic epitopes in rheumatoid arthritis. Nat Commun. 2023; 14(1):1061. PMC: 9958131. DOI: 10.1038/s41467-023-36620-y. View

Durai M, Gupta R, Moudgil K . The T cells specific for the carboxyl-terminal determinants of self (rat) heat-shock protein 65 escape tolerance induction and are involved in regulation of autoimmune arthritis. J Immunol. 2004; 172(5):2795-802. DOI: 10.4049/jimmunol.172.5.2795. View

Moudgil K, Sercarz E, Grewal I . Modulation of the immunogenicity of antigenic determinants by their flanking residues. Immunol Today. 1998; 19(5):217-20. DOI: 10.1016/s0167-5699(97)01233-4. View

Clement C, Osan J, Buque A, Nanaware P, Chang Y, Perino G . PDIA3 epitope-driven immune autoreactivity contributes to hepatic damage in type 2 diabetes. Sci Immunol. 2022; 7(74):eabl3795. PMC: 9762167. DOI: 10.1126/sciimmunol.abl3795. View

Manoil D, Courvoisier D, Gilbert B, Moller B, Walker U, Muehlenen I . Associations between serum antibodies to periodontal pathogens and preclinical phases of rheumatoid arthritis. Rheumatology (Oxford). 2021; 60(10):4755-4764. DOI: 10.1093/rheumatology/keab097. View

Hafkenscheid L, de Moel E, Smolik I, Tanner S, Meng X, Jansen B . N-Linked Glycans in the Variable Domain of IgG Anti-Citrullinated Protein Antibodies Predict the Development of Rheumatoid Arthritis. Arthritis Rheumatol. 2019; 71(10):1626-1633. PMC: 6790576. DOI: 10.1002/art.40920. View

10.

Schellekens G, Visser H, de Jong B, van den Hoogen F, Hazes J, Breedveld F . The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis Rheum. 2000; 43(1):155-63. DOI: 10.1002/1529-0131(200001)43:1<155::AID-ANR20>3.0.CO;2-3. View

11.

Oluwagbemigun K, Yucel-Lindberg T, Dietrich T, Tour G, Sherina N, Hansson M . A cross-sectional investigation into the association between and autoantibodies to citrullinated proteins in a German population. Ther Adv Musculoskelet Dis. 2019; 11:1759720X19883152. PMC: 6831975. DOI: 10.1177/1759720X19883152. View

12.

Dai Y, Sercarz E . Antigen processing patterns determine GAD65-specific regulation vs. pathogenesis. Front Biosci (Landmark Ed). 2009; 14(1):344-51. DOI: 10.2741/3248. View

13.

Lundberg K, Wegner N, Yucel-Lindberg T, Venables P . Periodontitis in RA-the citrullinated enolase connection. Nat Rev Rheumatol. 2010; 6(12):727-30. DOI: 10.1038/nrrheum.2010.139. View

14.

Durai M, Kim H, Moudgil K . The regulatory C-terminal determinants within mycobacterial heat shock protein 65 are cryptic and cross-reactive with the dominant self homologs: implications for the pathogenesis of autoimmune arthritis. J Immunol. 2004; 173(1):181-8. DOI: 10.4049/jimmunol.173.1.181. View

15.

Gregersen P, Silver J, Winchester R . The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum. 1987; 30(11):1205-13. DOI: 10.1002/art.1780301102. View

16.

Mori S, Naito H, Ohtani S, Yamanaka T, Sugimoto M . Diagnostic utility of anti-cyclic citrullinated peptide antibodies for rheumatoid arthritis in patients with active lung tuberculosis. Clin Rheumatol. 2008; 28(3):277-83. DOI: 10.1007/s10067-008-1035-5. View

17.

Moudgil K, Kim E, Yun O, CHI H, Brahn E, Sercarz E . Environmental modulation of autoimmune arthritis involves the spontaneous microbial induction of T cell responses to regulatory determinants within heat shock protein 65. J Immunol. 2001; 166(6):4237-43. DOI: 10.4049/jimmunol.166.6.4237. View

18.

Malcolm J, Nyirenda M, Brown J, Adrados-Planell A, Campbell L, Butcher J . C-terminal citrullinated peptide alters antigen-specific APC:T cell interactions leading to breach of immune tolerance. J Autoimmun. 2023; 135:102994. DOI: 10.1016/j.jaut.2023.102994. View

19.

Potempa J, Mydel P, Koziel J . The case for periodontitis in the pathogenesis of rheumatoid arthritis. Nat Rev Rheumatol. 2017; 13(10):606-620. DOI: 10.1038/nrrheum.2017.132. View

20.

Brewer R, Lanz T, Hale C, Sepich-Poore G, Martino C, Swafford A . Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis. Sci Transl Med. 2023; 15(684):eabq8476. PMC: 10496947. DOI: 10.1126/scitranslmed.abq8476. View