Surgical Management and Long-Term Evaluation of Pancreatic Neuroendocrine Tumors
Overview
Overview
Authors
Affiliations
Affiliations
Soon will be listed here.
Abstract
Pancreatic neuroendocrine tumors (PNETs) arise from neuroendocrine cells and are a rare class of heterogenous tumors with increasing incidence. The diagnosis, staging, treatment, and prognosis of PNETs depend heavily on identifying the histologic features and biological mechanisms. Here, the authors provide an overview of the diagnostic workup (biomarkers and imaging), grade, and staging of PNETs. The authors also explore associated genetic mutations and molecular pathways and describe updated guidelines on surgical and systemic treatment modalities.
References
1.
Oh C, Kim J, Lee J, Kim S, Kim T, Choi J
. Preoperative Chemoradiotherapy With Capecitabine With or Without Temozolomide in Patients With Locally Advanced Rectal Cancer: A Prospective, Randomised Phase II Study Stratified by O-Methylguanine DNA Methyltransferase Status: KCSG-CO17-02. Clin Oncol (R Coll Radiol). 2022; 35(2):e143-e152.
DOI: 10.1016/j.clon.2022.10.016.
View
2.
Howe J, Merchant N, Conrad C, Keutgen X, Hallet J, Drebin J
. The North American Neuroendocrine Tumor Society Consensus Paper on the Surgical Management of Pancreatic Neuroendocrine Tumors. Pancreas. 2019; 49(1):1-33.
PMC: 7029300.
DOI: 10.1097/MPA.0000000000001454.
View
3.
Pellat A, Cottereau A, Terris B, Coriat R
. Neuroendocrine Carcinomas of the Digestive Tract: What Is New?. Cancers (Basel). 2021; 13(15).
PMC: 8345167.
DOI: 10.3390/cancers13153766.
View
4.
Scott A, Howe J
. Evaluation and Management of Neuroendocrine Tumors of the Pancreas. Surg Clin North Am. 2019; 99(4):793-814.
PMC: 6601637.
DOI: 10.1016/j.suc.2019.04.014.
View
5.
Ruggeri R, Benevento E, De Cicco F, Fazzalari B, Guadagno E, Hasballa I
. Neuroendocrine neoplasms in the context of inherited tumor syndromes: a reappraisal focused on targeted therapies. J Endocrinol Invest. 2022; 46(2):213-234.
DOI: 10.1007/s40618-022-01905-4.
View