Efficacy and Safety of Belimumab Combined with the Standard Regimen in Treating Children with Lupus Nephritis

Overview

Journal Eur J Pediatr

Specialty Pediatrics

Date 2024 Jun 28

PMID 38940925

Authors

Huarong Li

Chaoying Chen

Hongxian Yang

Juan Tu

Affiliations

Soon will be listed here.

Abstract

Conclusion: With an equivalent renal remission rate, belimumab combined with the standard traditional regimen might promote the tapering of glucocorticoids, and the incidence of adverse events is low.

What Is Known: • Belimumab is documented as an adjunctive treatment with systemic lupus erythematosus (c-SLE) LN with efficacy. • Due to the paucity of studies, its effects and side effects in children with LN remain unclear.

What Is New: • This single-center, retrospective cohort study evaluated the efficacy and safety of belimumab combined with the standard regimen in treating children with proliferative LN. • Belimumab combined with the standard traditional treatment might promote the tapering of glucocorticoids, while exhibiting a low occurrence of adverse events.

Citing Articles

New Insights on Childhood Lupus Nephritis.

Marchi-Silva R, De Aquino B, Londe A, Mazzola T, Julio P, Wampler Muskardin T Int J Nephrol Renovasc Dis. 2025; 18():1-12.

PMID: 39829960 PMC: 11740589. DOI: 10.2147/IJNRD.S405789.

Efficacy of initial combination with belimumab in newly diagnosed childhood-onset lupus nephritis: a single-centre historical control study.

Gong Y, Liu S, Liu H, Shi Y, Li Y, Guan W Lupus Sci Med. 2024; 11(2).

PMID: 39675786 PMC: 11647295. DOI: 10.1136/lupus-2024-001350.

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