Adjuvant ArtinM Favored the Host Immunity Against Infection in C57BL/6 Mice

Overview

Journal Immunotherapy

Specialties Allergy & Immunology
Pharmacology

Date 2024 Jun 28

PMID 38940276

Authors

Patricia Kellen Martins Oliveira-Brito

Gabriela Yamazaki de Campos

Julia Garcia Guimaraes

Michele Procopio Machado

Leticia Costa Serafim

Javier Emilio Lazo Chica

Maria Cristina Roque-Barreira

Thiago Aparecido da Silva

Affiliations

Soon will be listed here.

Abstract

causes a severe fungal infection with high mortality rate among immunosuppressed and immunocompetent individuals. Due to limitation of current antifungal treatment, new immunotherapeutic approaches are explored. This study investigated an immunization strategy utilizing heat-inactivated with ArtinM as an adjuvant. C57BL/6 mice were intranasally immunized with heat-killed and ArtinM was administrated either before immunization or along with HK-. Mice were infected with and the efficacy of the immunization protocol was evaluated. Mice that received ArtinM exhibited increased levels of IL-10 and relative expression of IL-23 in the lungs, reduced fungal burden and preserved tissue integrity post-infection. Adjuvant ArtinM improved immunization against infection in C57BL/6 mice.

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