Reproductive Toxicity Perspectives of Nanoparticles: an Update

Overview

Journal Toxicol Res (Camb)

Publisher Oxford University Press

Date 2024 Jun 28

PMID 38939724

Authors

B Kavya Sree

Nitesh Kumar

Sanjiv Singh

Affiliations

Soon will be listed here.

Abstract

Introduction: The rapid development of nanotechnologies with their widespread prosperities has advanced concerns regarding potential health hazards of the Nanoparticles.

Results: Nanoparticles are currently present in several consumer products, including medications, food, textiles, sports equipment, and electrical components. Despite the advantages of Nanoparticles, their potential toxicity has negative impact on human health, particularly on reproductive health.

Conclusions: The impact of various NPs on reproductive system function is yet to be determined. Additional research is required to study the potential toxicity of various Nanoparticles on reproductive health. The primary objective of this review is to unravel the toxic effects of different Nanoparticles on the human reproductive functions and recent investigations on the reproductive toxicity of Nanoparticles both in vitro and in vivo.

Citing Articles

Prenatal Silicon Dioxide Nanoparticles Exposure Reduces Female Offspring Fertility Without Affecting Males.

Lei M, Zhu Z, Wei C, Xie H, Guo R, Zhao Y Adv Sci (Weinh). 2024; 12(3):e2410353.

PMID: 39574356 PMC: 11744561. DOI: 10.1002/advs.202410353.

References

Dutta B, Rakshe P, Maurya N, Chib S, Singh S . Unlocking the therapeutic potential of natural stilbene: Exploring pterostilbene as a powerful ally against aging and cognitive decline. Ageing Res Rev. 2023; 92:102125. DOI: 10.1016/j.arr.2023.102125. View

Manna P, Ghosh M, Ghosh J, Das J, Sil P . Contribution of nano-copper particles to in vivo liver dysfunction and cellular damage: role of IκBα/NF-κB, MAPKs and mitochondrial signal. Nanotoxicology. 2011; 6(1):1-21. DOI: 10.3109/17435390.2011.552124. View

Zharov V, Mercer K, Galitovskaya E, Smeltzer M . Photothermal nanotherapeutics and nanodiagnostics for selective killing of bacteria targeted with gold nanoparticles. Biophys J. 2005; 90(2):619-27. PMC: 1367066. DOI: 10.1529/biophysj.105.061895. View

Gomes S, Murphy M, Nielsen M, Kristiansen S, Amorim M, Scott-Fordsmand J . Cu-nanoparticles ecotoxicity--explored and explained?. Chemosphere. 2015; 139:240-5. DOI: 10.1016/j.chemosphere.2015.06.045. View

Ward J, Kach D . Marine aggregates facilitate ingestion of nanoparticles by suspension-feeding bivalves. Mar Environ Res. 2009; 68(3):137-42. DOI: 10.1016/j.marenvres.2009.05.002. View

Buchman J, Hudson-Smith N, Landy K, Haynes C . Understanding Nanoparticle Toxicity Mechanisms To Inform Redesign Strategies To Reduce Environmental Impact. Acc Chem Res. 2019; 52(6):1632-1642. DOI: 10.1021/acs.accounts.9b00053. View

Lan Z, Yang W . Nanoparticles and spermatogenesis: how do nanoparticles affect spermatogenesis and penetrate the blood-testis barrier. Nanomedicine (Lond). 2012; 7(4):579-96. DOI: 10.2217/nnm.12.20. View

Adam N, Schmitt C, Galceran J, Companys E, Vakurov A, Wallace R . The chronic toxicity of ZnO nanoparticles and ZnCl2 to Daphnia magna and the use of different methods to assess nanoparticle aggregation and dissolution. Nanotoxicology. 2013; 8(7):709-17. DOI: 10.3109/17435390.2013.822594. View

Warren M, Perlroth N . The effects of intense exercise on the female reproductive system. J Endocrinol. 2001; 170(1):3-11. DOI: 10.1677/joe.0.1700003. View

10.

Brown D, Wilson M, MacNee W, Stone V, Donaldson K . Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines. Toxicol Appl Pharmacol. 2001; 175(3):191-9. DOI: 10.1006/taap.2001.9240. View

11.

Chen J, Wang H, Long W, Shen X, Wu D, Song S . Sex differences in the toxicity of polyethylene glycol-coated gold nanoparticles in mice. Int J Nanomedicine. 2013; 8:2409-19. PMC: 3707481. DOI: 10.2147/IJN.S46376. View

12.

Fent K, Weisbrod C, Wirth-Heller A, Pieles U . Assessment of uptake and toxicity of fluorescent silica nanoparticles in zebrafish (Danio rerio) early life stages. Aquat Toxicol. 2010; 100(2):218-28. DOI: 10.1016/j.aquatox.2010.02.019. View

13.

Bakand S, Hayes A, Dechsakulthorn F . Nanoparticles: a review of particle toxicology following inhalation exposure. Inhal Toxicol. 2012; 24(2):125-35. DOI: 10.3109/08958378.2010.642021. View

14.

Salustri A, Campagnolo L, Klinger F, Camaioni A . Molecular organization and mechanical properties of the hyaluronan matrix surrounding the mammalian oocyte. Matrix Biol. 2018; 78-79:11-23. DOI: 10.1016/j.matbio.2018.02.002. View

15.

Hillier S . Current concepts of the roles of follicle stimulating hormone and luteinizing hormone in folliculogenesis. Hum Reprod. 1994; 9(2):188-91. DOI: 10.1093/oxfordjournals.humrep.a138480. View

16.

ONeal D, Hirsch L, Halas N, Payne J, West J . Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles. Cancer Lett. 2004; 209(2):171-6. DOI: 10.1016/j.canlet.2004.02.004. View

17.

Nowack B, Bucheli T . Occurrence, behavior and effects of nanoparticles in the environment. Environ Pollut. 2007; 150(1):5-22. DOI: 10.1016/j.envpol.2007.06.006. View

18.

Bartneck M, Ritz T, Keul H, Wambach M, Bornemann J, Gbureck U . Peptide-functionalized gold nanorods increase liver injury in hepatitis. ACS Nano. 2012; 6(10):8767-77. DOI: 10.1021/nn302502u. View

19.

Singh S, Changkija S, Mudgal R, Ravichandiran V . Bioactive components to inhibit foam cell formation in atherosclerosis. Mol Biol Rep. 2022; 49(3):2487-2501. DOI: 10.1007/s11033-021-07039-9. View

20.

Abbasalipourkabir R, Moradi H, Zarei S, Asadi S, Salehzadeh A, Ghafourikhosroshahi A . Toxicity of zinc oxide nanoparticles on adult male Wistar rats. Food Chem Toxicol. 2015; 84:154-60. DOI: 10.1016/j.fct.2015.08.019. View