Detection of Placental-type Alkaline Phosphatase in Ovarian Cancer

Overview

Journal Br J Cancer

Specialty Oncology

Date 1985 Jul 1

PMID 3893506

Citations 8

Authors

I W McDicken

P J McLaughlin

P M Tromans

D M Luesley

P M Johnson

Affiliations

Soon will be listed here.

Abstract

A monoclonal antibody, H317, has been used for the sensitive and specific detection of placental-type alkaline phosphatase (PLAP) in sera, solubilized tissue extracts and fixed tumour tissue sections from patients representing a variety of ovarian tumours. PLAP was detected in over 30% of these sera and in most solubilized tumour tissue extracts. There was no association between circulating PLAP levels and either tissue extract levels or immunohistological staining of ovarian tumour tissue sections with H317. Nevertheless, immunohistology demonstrated the heterogeneity of cellular localization of PLAP within different tumours, and can often be of value in localizing tumour tissue.

Citing Articles

Pattern of placental alkaline phosphatase (PLAP) expression in human tumors: a tissue microarray study on 12,381 tumors.

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Serum placental-type alkaline phosphatase activity in women with squamous and glandular malignancies of the reproductive tract.

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Tumor markers in the human ovary and its neoplasms. A comparative immunohistochemical study.

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A 72 kD trophoblast glycoprotein defined by a monoclonal antibody.

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Placental-type alkaline phosphatase in cervical neoplasia.

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