The Positive Association Between Hyperuricemia and Polycystic Ovary Syndrome and Analysis of Related Factors

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2024 Jun 27

PMID 38933825

Authors

Zhentao Gong

Yanwen Sun

Lingshan Zhang

Xiaoyong Zhu

Yingli Shi

Affiliations

Soon will be listed here.

Abstract

Purpose: To examine the potential association between polycystic ovary syndrome (PCOS) and hyperuricemia and to elucidate the underlying contributory factors.

Methods: Retrospective study on 603 women with PCOS and 604 women without PCOS. Anthropometric features, reproductive hormone profiles, and metabolic parameters were measured and compared between two groups of patients. Examinations of correlations between SUA levels and other parameters were conducted to discern potential correlations.

Results: Both serum uric acid levels and the incidence of hyperuricemia exhibited statistically significant elevations in women with PCOS when compared to their counterparts without PCOS. Nonetheless, this statistical difference was not found between the obese subgroup after stratifying study subjects by body mass index (BMI). Pearson's correlation analysis underscored the prominence of BMI as a robust factor influencing SUA levels in women, regardless of their PCOS status. Furthermore, multivariable linear regression model demonstrated significant positive associations between SUA levels and several variables, namely dehydroepiandrosterone sulfate (DHEA-S), free androgen index (FAI), total cholesterol (TC), triglycerides (TG), free fatty acids (FFA), fasting insulin (FINS), homeostatic model assessment of insulin resistance (HOMA-IR), area under the curve for insulin (AUC-I), alanine aminotransferase (ALT), and aspartate aminotransferase (AST). Additionally, it is noteworthy that the prevalence of hyperuricemia exhibited a positive association with fasting plasma glucose (FPG) levels, while conversely, it displayed a negative association with estradiol (E2) levels.

Conclusions: PCOS is associated with a significant elevation of SUA level and hyperuricemia prevalence. HA, IR, and dyslipidemia may be the mediators in the pathogenesis of hyperuricemia in women with PCOS.

Citing Articles

Effect of Dietary Magnesium on the Association Between Serum Uric Acid and Female Infertility.

Xin X, Zhang Q, Xu J, Huang J Int J Womens Health. 2025; 17():33-42.

PMID: 39802919 PMC: 11725261. DOI: 10.2147/IJWH.S484872.

The Underlying Effect of Urate Levels on Female Infertility.

Naveed M, Hill J Metabolites. 2024; 14(10).

PMID: 39452945 PMC: 11509475. DOI: 10.3390/metabo14100564.

References

Bonora E, Targher G, Zenere M, Saggiani F, Cacciatori V, Tosi F . Relationship of uric acid concentration to cardiovascular risk factors in young men. Role of obesity and central fat distribution. The Verona Young Men Atherosclerosis Risk Factors Study. Int J Obes Relat Metab Disord. 1996; 20(11):975-80. View

Avram Z, Krishnan E . Hyperuricaemia--where nephrology meets rheumatology. Rheumatology (Oxford). 2008; 47(7):960-4. DOI: 10.1093/rheumatology/ken070. View

Facchini F, Chen Y, Hollenbeck C, Reaven G . Relationship between resistance to insulin-mediated glucose uptake, urinary uric acid clearance, and plasma uric acid concentration. JAMA. 1991; 266(21):3008-11. View

Fukai S, Akishita M, Miyao M, Ishida K, Toba K, Ouchi Y . Age-related changes in plasma androgen levels and their association with cardiovascular risk factors in male Japanese office workers. Geriatr Gerontol Int. 2010; 10(1):32-9. DOI: 10.1111/j.1447-0594.2009.00552.x. View

Choi H, Ford E . Haemoglobin A1c, fasting glucose, serum C-peptide and insulin resistance in relation to serum uric acid levels--the Third National Health and Nutrition Examination Survey. Rheumatology (Oxford). 2008; 47(5):713-7. DOI: 10.1093/rheumatology/ken066. View

Johnson R, Lanaspa M, Gaucher E . Uric acid: a danger signal from the RNA world that may have a role in the epidemic of obesity, metabolic syndrome, and cardiorenal disease: evolutionary considerations. Semin Nephrol. 2011; 31(5):394-9. PMC: 3203212. DOI: 10.1016/j.semnephrol.2011.08.002. View

de Sousa G, Brodoswki C, Kleber M, Wunsch R, Reinehr T . Association between androgens, intima-media thickness and the metabolic syndrome in obese adolescent girls. Clin Endocrinol (Oxf). 2009; 72(6):770-4. DOI: 10.1111/j.1365-2265.2009.03710.x. View

Pizzichini M, Di Stefano A, Resconi G, Pompucci G, Marinello E . Influence of testosterone on purine nucleotide turnover in rat kidney. Horm Metab Res. 1990; 22(6):334-8. DOI: 10.1055/s-2007-1004914. View

HERMAN J, Goldbourt U . Uric acid and diabetes: observations in a population study. Lancet. 1982; 2(8292):240-3. DOI: 10.1016/s0140-6736(82)90324-5. View

10.

Levey A, Stevens L, Schmid C, Zhang Y, Castro 3rd A, Feldman H . A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009; 150(9):604-12. PMC: 2763564. DOI: 10.7326/0003-4819-150-9-200905050-00006. View

11.

Franks S . Polycystic ovary syndrome. N Engl J Med. 1995; 333(13):853-61. DOI: 10.1056/NEJM199509283331307. View

12.

Barry J, Azizia M, Hardiman P . Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod Update. 2014; 20(5):748-58. PMC: 4326303. DOI: 10.1093/humupd/dmu012. View

13.

Kuhns V, Woodward O . Sex Differences in Urate Handling. Int J Mol Sci. 2020; 21(12). PMC: 7349092. DOI: 10.3390/ijms21124269. View

14.

Wan H, Zhang K, Wang Y, Chen Y, Zhang W, Xia F . The Associations Between Gonadal Hormones and Serum Uric Acid Levels in Men and Postmenopausal Women With Diabetes. Front Endocrinol (Lausanne). 2020; 11:55. PMC: 7044188. DOI: 10.3389/fendo.2020.00055. View

15.

Adamopoulos D, Vlassopoulos C, Seitanides B, Contoyiannis P, Vassilopoulos P . The relationship of sex steroids to uric acid levels in plasma and urine. Acta Endocrinol (Copenh). 1977; 85(1):198-208. DOI: 10.1530/acta.0.0850198. View

16.

Mu L, Pan J, Yang L, Chen Q, Chen Y, Teng Y . Association between the prevalence of hyperuricemia and reproductive hormones in polycystic ovary syndrome. Reprod Biol Endocrinol. 2018; 16(1):104. PMC: 6203189. DOI: 10.1186/s12958-018-0419-x. View

17.

Legro R, Kunselman A, Dodson W, Dunaif A . Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women. J Clin Endocrinol Metab. 1999; 84(1):165-9. DOI: 10.1210/jcem.84.1.5393. View

18.

Oberbach A, Neuhaus J, Schlichting N, Kugler J, Baumann S, Till H . Sleeve gastrectomy reduces xanthine oxidase and uric acid in a rat model of morbid obesity. Surg Obes Relat Dis. 2014; 10(4):684-90. DOI: 10.1016/j.soard.2013.12.010. View

19.

Osibogun O, Ogunmoroti O, Michos E . Polycystic ovary syndrome and cardiometabolic risk: Opportunities for cardiovascular disease prevention. Trends Cardiovasc Med. 2019; 30(7):399-404. DOI: 10.1016/j.tcm.2019.08.010. View

20.

. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004; 81(1):19-25. DOI: 10.1016/j.fertnstert.2003.10.004. View